Experimental study on effect of tonifying Kidney herbs on pituitary, ovary, and adrenal gland in androgen sterilized rats

Gui Suiqi; Yu Jin; Wei Meijuan; Yang Shuping; Shi Dawen

doi:10.1007/BF02934057

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Experimental study on effect of tonifying Kidney herbs on pituitary, ovary, and adrenal gland in androgen sterilized rats

Updated：2021-08-27

- Experimental study on effect of tonifying Kidney herbs on pituitary, ovary, and adrenal gland in androgen sterilized rats
- Chinese Journal of Integrative Medicine Vol. 4, Issue 3, Pages: 189-193(1998)
- Affiliations：
  
  The Gynecology and Obstetrics Hospital of Shanghai Medical University,Shanghai
- Author bio：
- Funds：
  
  This is an item of National Foundation of Nature Science
- DOI：10.1007/BF02934057
  CLC：
- Published：1998，
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Gui, S., Yu, J., Wei, M. et al. Experimental study on effect of tonifying Kidney herbs on pituitary, ovary, and adrenal gland in androgen sterilized rats., CJIM 4, 189–193 (1998). https://doi.org/10.1007/BF02934057

Gui Suiqi, Yu Jin, Wei Meijuan, et al. Experimental study on effect of tonifying Kidney herbs on pituitary, ovary, and adrenal gland in androgen sterilized rats. [J]. Chinese Journal of Integrative Medicine 4(3):189-193(1998)
Gui, S., Yu, J., Wei, M. et al. Experimental study on effect of tonifying Kidney herbs on pituitary, ovary, and adrenal gland in androgen sterilized rats., CJIM 4, 189–193 (1998). https://doi.org/10.1007/BF02934057 DOI：

Gui Suiqi, Yu Jin, Wei Meijuan, et al. Experimental study on effect of tonifying Kidney herbs on pituitary, ovary, and adrenal gland in androgen sterilized rats. [J]. Chinese Journal of Integrative Medicine 4(3):189-193(1998) DOI： 10.1007/BF02934057.

摘要

Objective: To observe the effect of tonifying Kidney herbs (TKH) on pituitary gland

ovary

and adrenal gland of androgen sterilized rats (ASR).Methods: ASR model was established by injecting testosterone propionate subcutaneously to Sprague-Dawley (SD) female rats of 9 days age. Morphological and endocrinological change of pituitary gland

ovary and adrenal gland in rats of 100–107 days old before and after feeding TKH extract were observed by light and electron microscope

cell cultures

immunohistochemical studies

and radioimmunoassay.Results: In the ASR groups

there were intracytoplasmic lipid drops

crinophagy

vacuole

and autophagy in pituitary gland

anovulation in ovary

and hyperplasia of reticular zone in adrenal gland. At the same time

serum follicular stimulating hormone and luteinizing hormone decreased (P < 0.05-0.005) and serum testosterone and dehydroepiandrosterone levels increased significantly (P < 0.01-0.001). These morphologiacl and endocrinological changes were all returned to normal range after the TKH treatment.

Abstract

Objective: To observe the effect of tonifying Kidney herbs (TKH) on pituitary gland

ovary

ovary and adrenal gland in rats of 100–107 days old before and after feeding TKH extract were observed by light and electron microscope

cell cultures

immunohistochemical studies

and radioimmunoassay.Results: In the ASR groups

there were intracytoplasmic lipid drops

crinophagy

vacuole

and autophagy in pituitary gland

anovulation in ovary

and hyperplasia of reticular zone in adrenal gland. At the same time

关键词

tonifying Kidney herbsandrogen sterilized ratmorphologyendocrinesex gland axisadrenal gland

Keywords

tonifying Kidney herbsandrogen sterilized ratmorphologyendocrinesex gland axisadrenal gland

references

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1987; 1 (1): 209–212.

Terrey TH, William JL. The effects of corticotropin, opioid peptides and crude pituitary extract on the production of dehydroepiandrosterone and corticosterone by mature rat adrenal cells in tissue culture. J Steroid Biochem 1988; 29 (6):721–724.

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Department of Traditional Chinese Medicine, Translational Medicine Center, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences

Medical College, Yangzhou University

Institute for the Integration of Traditional Chinese and Western Medicine, First Hospital, Beijing Medical University

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