Effect of purified Xuefu Capsule on endothelin, nitric oxide synthetase gene expression of vascular wall in atherosclerotic rabbits

Dazhuo Shi; Keji Chen; Qunhao Zhang; Pei Zhong; Yingbao Zhu; Xin Fu

doi:10.1007/BF02934158

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Effect of purified Xuefu Capsule on endothelin, nitric oxide synthetase gene expression of vascular wall in atherosclerotic rabbits

Updated：2021-08-27

- Effect of purified Xuefu Capsule on endothelin, nitric oxide synthetase gene expression of vascular wall in atherosclerotic rabbits
- Chinese Journal of Integrative Medicine Vol. 4, Issue 2, Pages: 123-125(1998)
- Affiliations：
  
  1. Xiyuan Hospital, China Academy of TCM,Beijing
  2. The Third Clinical College, Beijing Medical University,Beijing
- Author bio：
- Funds：
- DOI：10.1007/BF02934158
  CLC：
- Published：1998，
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Shi, D., Chen, K., Zhang, Q. et al. Effect of purified Xuefu Capsule on endothelin, nitric oxide synthetase gene expression of vascular wall in atherosclerotic rabbits., CJIM 4, 123–125 (1998). https://doi.org/10.1007/BF02934158

Dazhuo Shi, Keji Chen, Qunhao Zhang, et al. Effect of purified Xuefu Capsule on endothelin, nitric oxide synthetase gene expression of vascular wall in atherosclerotic rabbits. [J]. Chinese Journal of Integrative Medicine 4(2):123-125(1998)
Shi, D., Chen, K., Zhang, Q. et al. Effect of purified Xuefu Capsule on endothelin, nitric oxide synthetase gene expression of vascular wall in atherosclerotic rabbits., CJIM 4, 123–125 (1998). https://doi.org/10.1007/BF02934158 DOI：

Dazhuo Shi, Keji Chen, Qunhao Zhang, et al. Effect of purified Xuefu Capsule on endothelin, nitric oxide synthetase gene expression of vascular wall in atherosclerotic rabbits. [J]. Chinese Journal of Integrative Medicine 4(2):123-125(1998) DOI： 10.1007/BF02934158.

摘要

Objective: To observe the effect of purified Xuefu Capsule (PXC) on endothelin (ET) and nitric oxide synthetase (NOS) gene expression and proliferation of vascular smooth muscle cell (VSMC) in atherosclerotic rabbits.Methods: Molecular biological techniques of dot blot and in situ hybridization were adopted.Results: The expression of ET mRNA in atherosclerosis (AS)

plaques of the model group was higher

with the positive signals distributed mainly in arterial intimal AS plaques; while at the same time the expression in the PXC treated group was lower

with only few scattering signals found in arterial intimal AS plaques. NOS mRNA expression was less in the vascular wall of the AS model group

PXC could enhance NOS mRNA expression

positive signals could be found from intima to media.Conclusion: The effect of PXC on preventing and treating AS might be related to regulating the expression of ET mRNA and NOS mRNA in the vascular wall.

Abstract

plaques of the model group was higher

with the positive signals distributed mainly in arterial intimal AS plaques; while at the same time the expression in the PXC treated group was lower

with only few scattering signals found in arterial intimal AS plaques. NOS mRNA expression was less in the vascular wall of the AS model group

PXC could enhance NOS mRNA expression

关键词

purified Xuefu capsuleendothelinnitric oxide synthetase

Keywords

purified Xuefu capsuleendothelinnitric oxide synthetase

references

Frederick M, Robert E, David D, et al. Short protocols in molecular biology. Greene Publishing Association and Jone Wiley & Sons, 2 ed. New York; 1992: 4–23.

Chomezinski P, Sacchi N. RNA isolation by acidguandinium thiocyanate-pheno-choloroform extraction. Anal biochem 1987;162: 156.

Nathan C. Nitric oxide as a secretory product of mammalian cells. FASEBJ 1992; 6: 3051.

Lerman A, Edwards BS, Hallett JW, et al. Circulating and tissue endothelin immunoreactivity in advanced atherosclerosis. New Engl J Med 1991;325(14): 997.

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Fundamental Medical Sciences Center, Xiyuan Hospital, China Academy of Chinese Medical Sciences

Department of Radioisotope, Qilu Hospital Affiliated to Shandong University

Department of TCM, Qilu Hospital Affiliated to Shandong University

Hospital of Zhejiang University

The First Affiliated Hospital of Guangzhou University of TCM

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