Effect of Reduqing on plasma lnterleukin-8 and nitric oxide in rabbits with endotoxin induced disseminated intravascular coagulation

Guang Yang; Mingzhen Li; Yanping Zhang; Baoying Lin; Lijun Xu; Kaifu Wang; Mingwei Yang; Chaodong Wu

doi:10.1007/BF02934159

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Effect of Reduqing on plasma lnterleukin-8 and nitric oxide in rabbits with endotoxin induced disseminated intravascular coagulation

Updated：2021-08-27

- Effect of Reduqing on plasma lnterleukin-8 and nitric oxide in rabbits with endotoxin induced disseminated intravascular coagulation
- Chinese Journal of Integrative Medicine Vol. 4, Issue 2, Pages: 126-130(1998)
- Affiliations：
  
  Institute of Integrated Traditional Chinese and Western Medicine, Tongji Medical University,Wuhan
- Author bio：
- Funds：
- DOI：10.1007/BF02934159
  CLC：
- Published：1998，
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Yang, G., Li, M., Zhang, Y. et al. Effect of Reduqing on plasma lnterleukin-8 and nitric oxide in rabbits with endotoxin induced disseminated intravascular coagulation., CJIM 4, 126–130 (1998). https://doi.org/10.1007/BF02934159

Guang Yang, Mingzhen Li, Yanping Zhang, et al. Effect of Reduqing on plasma lnterleukin-8 and nitric oxide in rabbits with endotoxin induced disseminated intravascular coagulation. [J]. Chinese Journal of Integrative Medicine 4(2):126-130(1998)
Yang, G., Li, M., Zhang, Y. et al. Effect of Reduqing on plasma lnterleukin-8 and nitric oxide in rabbits with endotoxin induced disseminated intravascular coagulation., CJIM 4, 126–130 (1998). https://doi.org/10.1007/BF02934159 DOI：

Guang Yang, Mingzhen Li, Yanping Zhang, et al. Effect of Reduqing on plasma lnterleukin-8 and nitric oxide in rabbits with endotoxin induced disseminated intravascular coagulation. [J]. Chinese Journal of Integrative Medicine 4(2):126-130(1998) DOI： 10.1007/BF02934159.

摘要

Objective: To investigate the effects of Reduqing (RDQ

) on plasma interleukin-8 (IL-8)

NO2 - /NO3 -

complement 5a (C5a) and polymorphonuclear neutrophilic leukocyte (PMN) chemotaxis Index (CI) in rabbits with endotoxin-induced disseminated intravascular coagulation (DIC).Methods: Endotoxin-in-duced DIC model made by injection of Lipopolysacchrides (LPS) was used in the experiment. Above-mentioned indexes were determined before and after RDQ treatment and compared with blank and dexamethasone treated group.Results: Plasma IL-8

NO2 - /NO3 -

C5a and CI level of PMN increased markedly in the model group

which were confirmed pathologically with obvious damage of tissues or organs. In the RDQ group

the abovem entiond parameters and damage of tissues or organs were reduced significantly (P < 0.01).Conclusion: IL-8 and NO might be involved in pathogenesis of endotoxin-induced DIC

and RDQ could be used in preventing or treating DIC through the mechanism of regulation of cytokines network.

Abstract

Objective: To investigate the effects of Reduqing (RDQ

) on plasma interleukin-8 (IL-8)

NO2 - /NO3 -

C5a and CI level of PMN increased markedly in the model group

which were confirmed pathologically with obvious damage of tissues or organs. In the RDQ group

the abovem entiond parameters and damage of tissues or organs were reduced significantly (P < 0.01).Conclusion: IL-8 and NO might be involved in pathogenesis of endotoxin-induced DIC

and RDQ could be used in preventing or treating DIC through the mechanism of regulation of cytokines network.

关键词

interleukin-8Nitric OxideInjectio Reduqingdisseminated intravascular coagulationcomplementchemotaxis

Keywords

interleukin-8Nitric OxideInjectio Reduqingdisseminated intravascular coagulationcomplementchemotaxis

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Searle-Monsanto Co., Chesterfield

Institute of Integration of Traditional and Western Medicine, Tongji Medical University

Department of Hematology, the Affiliated Hospital of Guiyang Medical College

Key Laboratory of Basic Pharmacology of Guizhou and Department of Pharmacology, Zunyi Medical College

Department of Physiology, Bengbu Medical College

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