Single-dose methotrexate Combined with Chinese medicinal herbs treated unruptured and ruptured ectopic pregnancy

Wang Jianhua; Yu Zaiji

doi:10.1007/BF02934188

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Single-dose methotrexate Combined with Chinese medicinal herbs treated unruptured and ruptured ectopic pregnancy

Updated：2021-08-27

- Single-dose methotrexate Combined with Chinese medicinal herbs treated unruptured and ruptured ectopic pregnancy
- Chinese Journal of Integrative Medicine Vol. 5, Issue 1, Pages: 41-45(1999)
- Affiliations：
  
  Institute of Activating Blood Circulation to Remove Stasis, Gynecopathy of Shanxi Province,Taiyuan
- Author bio：
- Funds：
- DOI：10.1007/BF02934188
  CLC：
- Published：1999，
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Jianhua, W., Zaiji, Y. Single-dose methotrexate Combined with Chinese medicinal herbs treated unruptured and ruptured ectopic pregnancy., CJIM 5, 41–45 (1999). https://doi.org/10.1007/BF02934188

Wang Jianhua, Yu Zaiji. Single-dose methotrexate Combined with Chinese medicinal herbs treated unruptured and ruptured ectopic pregnancy. [J]. Chinese Journal of Integrative Medicine 5(1):41-45(1999)
Jianhua, W., Zaiji, Y. Single-dose methotrexate Combined with Chinese medicinal herbs treated unruptured and ruptured ectopic pregnancy., CJIM 5, 41–45 (1999). https://doi.org/10.1007/BF02934188 DOI：

Wang Jianhua, Yu Zaiji. Single-dose methotrexate Combined with Chinese medicinal herbs treated unruptured and ruptured ectopic pregnancy. [J]. Chinese Journal of Integrative Medicine 5(1):41-45(1999) DOI： 10.1007/BF02934188.

摘要

Objective: To explore the therapeutic effect of single-dose methotrexate (MTX) with Chinese medicinal herbs in the treatment of ectopic pregnancy(EP).Methods: Eighty-five patients with unruptured and ruptured EP were prospectively treated with an intramuscular injection of MTX (50 mg/m2) without citrovorum factor rescue to destroy embryo and villi

meanwhile

EP 1 decoction was given orally

in the case of ruptured EP with active internal hemorrhage resulted from EP mass rupture

or EP 2 decoction was given orally

in the case of unruptured EP and ruptured EP without active internal hemorrhage resulted from EP mass rhexis and blood in the peritoneal cavity has already formed hematomas. The serum human chorionic gonadotropin (hCG) (3-subunit were monitored regularly until they were undetectable. Serial B-ultrasound examinations were followed up by observing the gestational sac

fetal cardiac activity

EP mass absorption

etc. Of those who has the desire of being pregnant

after all EP mass disappeared

hysterosalpingogram may be performed.Results: The total of 81 cases (95.3%) were successfully treated without surgical operation

4 cases (4.7%) required surgical management of EP. The mean serum hCG β-subunit clearance time was 18.7 β 7.2 days. Total disappearance of EP mass assessed by transvaginal ultrasonography

was 1.2 β 0.7 months. Hysterosalpingograms done on 20 patients of attempting pregnancy subsequently demonstrated tubal patency in 90.0% (18 cases) on the affected side. To date

15 intrauterine pregnancies have occurred in this group

none of the patients were recurrent EP.Conclusions: EP were treated with integrated traditional Chinese and western medicine

it may expand the EP indication treated with MTX alone

elevate cure rate and obtain ideal efficacy without surgical intervention.

Abstract

meanwhile

EP 1 decoction was given orally

in the case of ruptured EP with active internal hemorrhage resulted from EP mass rupture

or EP 2 decoction was given orally

fetal cardiac activity

EP mass absorption

etc. Of those who has the desire of being pregnant

after all EP mass disappeared

hysterosalpingogram may be performed.Results: The total of 81 cases (95.3%) were successfully treated without surgical operation

4 cases (4.7%) required surgical management of EP. The mean serum hCG β-subunit clearance time was 18.7 β 7.2 days. Total disappearance of EP mass assessed by transvaginal ultrasonography

was 1.2 β 0.7 months. Hysterosalpingograms done on 20 patients of attempting pregnancy subsequently demonstrated tubal patency in 90.0% (18 cases) on the affected side. To date

15 intrauterine pregnancies have occurred in this group

none of the patients were recurrent EP.Conclusions: EP were treated with integrated traditional Chinese and western medicine

it may expand the EP indication treated with MTX alone

elevate cure rate and obtain ideal efficacy without surgical intervention.

关键词

ectopic pregnancymethotrexateChinese medicinal herbs

Keywords

ectopic pregnancymethotrexateChinese medicinal herbs

references

Stovall TG, Ling FW. Single-dose methotrexate: an expanded clinical trial. Am J Obstet Gynecol 1993; 168(6): 1759–1765.

Patsner B, Kenigsberg D. Successful treatment of persistent ectopic pregnancy with oral methotrexate therapy. Fertil Steril 1988; 50(6): 982–983.

Menard A, Crequat J, Mandelbrot L, et al. Treatment of unruptured tubal pregnancy by local injection of methotrexate under transvaginal sonographic control. Fertil Steril 1990; 54(1): 450.

Cannon L, Jesionwska H. Methotrexate treatment of tubal pregnancy. Fertil Steril 1991; 55(6): 1033–1038.

Corsan GH, Karacan M, Qasim S, et al. Identification of hormonal parameters for successfully systemic single-dose methotrexate therapy in ectopic pregnancy. Hum Reprod 1995; 10(10): 2719–2722.

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Herve F, Christophe L, Philippe B, et al. Treatment of unruptured tubal pregnancy with methotrexate: pharmacokinetic analysis of local versus intramuscular administration. Fertil Steril 1994; 62 (5): 943–947.

Petra J, Ben WJ, Ralph R, et al. Serum human chorionic gonadotropin clearance curves in patients with interstitial pregnancy treated with systemic methotrexate. Fertil Steril 1996; 66(5): 723–728.

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Hospital of Maternal and Child Health Care of Shanxi Province

Institute of Activating Blood Circulation to Removing Stasis, Gynecopathy of Shanxi Province

Eye Institute of Shandong University of Traditional Chinese Medicine

Mobile Postdoctoral Stations of Traditional Chinese Medical Science, Shandong University of Traditional Chinese Medicine

School of Information Management, Shandong University of Traditional Chinese Medicine

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