Protective effects of Radix Astragalus on vascular endothelial Cells of patients with Binswanger’s disease

Chen Chunfu; Jia Haiyan; Guo Shusu; Chen Tonghui; Wang Hede

doi:10.1007/BF02934189

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Protective effects of Radix Astragalus on vascular endothelial Cells of patients with Binswanger’s disease

Updated：2021-08-27

- Protective effects of Radix Astragalus on vascular endothelial Cells of patients with Binswanger’s disease
- Chinese Journal of Integrative Medicine Vol. 5, Issue 1, Pages: 46-49(1999)
- Affiliations：
  
  Department of Neurology, Jinan Military General Hospital,Jinan
- Author bio：
- Funds：
- DOI：10.1007/BF02934189
  CLC：
- Published：1999，
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Chunfu, C., Haiyan, J., Shusu, G. et al. Protective effects of Radix Astragalus on vascular endothelial Cells of patients with Binswanger’s disease., CJIM 5, 46 (1999). https://doi.org/10.1007/BF02934189

Chen Chunfu, Jia Haiyan, Guo Shusu, et al. Protective effects of Radix Astragalus on vascular endothelial Cells of patients with Binswanger’s disease. [J]. Chinese Journal of Integrative Medicine 5(1):46-49(1999)
Chunfu, C., Haiyan, J., Shusu, G. et al. Protective effects of Radix Astragalus on vascular endothelial Cells of patients with Binswanger’s disease., CJIM 5, 46 (1999). https://doi.org/10.1007/BF02934189 DOI：

Chen Chunfu, Jia Haiyan, Guo Shusu, et al. Protective effects of Radix Astragalus on vascular endothelial Cells of patients with Binswanger’s disease. [J]. Chinese Journal of Integrative Medicine 5(1):46-49(1999) DOI： 10.1007/BF02934189.

摘要

Objective: To compare the effects of Radix Astragalus (RA) on vascular endothelial cells in Binswanger’s disease (BD) patients with Radix Salviae miltiorrhizae (RSM).Methods: There were 37 patients with BD in the treated group and 37 healthy subjects in the control group. Thirty-seven patients were further randomly subdivided into two groups: RA group (19 patients) and RSM group (18 patients). Circulating endothelial cells (CEC) and the levels of endothelin-1 (ET-1)

nitric oxide (NO) and malondialdehyde (MDA) in the blood of internal jugular vein which were examined before and after treatments.Results: When compared with those of the control group

CEC counts

ET-1 and MDA levels in plasma increased significantly

meanwhile serum NO concentration decreased significantly in the treated group. When compared with those of pretreatment

CEC counts

ET-1 and MDA decreased significantly and serum NO concentration increased significantly after treatment in RA group. There were no significant changes of these indices in RSM group after treatment.Conclusions: There are damage and dysfunction of vascular endothelial cells in patients with BD. RA injection is an effective drug to protect vascular endothelial cells of BD patients.

Abstract

nitric oxide (NO) and malondialdehyde (MDA) in the blood of internal jugular vein which were examined before and after treatments.Results: When compared with those of the control group

CEC counts

ET-1 and MDA levels in plasma increased significantly

meanwhile serum NO concentration decreased significantly in the treated group. When compared with those of pretreatment

CEC counts

关键词

Binswanger’s diseaseVascular Dementiacirculating endothelial cellsRadix AstragalusRadix Salviae Miltiorrhizae

Keywords

Binswanger’s diseaseVascular Dementiacirculating endothelial cellsRadix AstragalusRadix Salviae Miltiorrhizae

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