Effects of supplemented Taohe Chengqi Decoction in treating insulin resistance in rats with non-insulin Dependent Diabetes Mellitus) in treating insulin resistance in rats with non-insulin Dependent Diabetes Mellitus

Xiong Manqi; Lin Anzhong; Zhu Zhangzhi; Cai Wenjiu; Zheng Gaofei; Zhong Chunning; Chen Zhixi; Jia Keliang; Shen Suiting; He Min

doi:10.1007/BF02934192

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Effects of supplemented Taohe Chengqi Decoction in treating insulin resistance in rats with non-insulin Dependent Diabetes Mellitus) in treating insulin resistance in rats with non-insulin Dependent Diabetes Mellitus

Updated：2021-08-27

- Effects of supplemented Taohe Chengqi Decoction in treating insulin resistance in rats with non-insulin Dependent Diabetes Mellitus) in treating insulin resistance in rats with non-insulin Dependent Diabetes Mellitus
- Chinese Journal of Integrative Medicine Vol. 5, Issue 1, Pages: 54-58(1999)
- Affiliations：
  
  First Affiliated Hospital, Guangzhou University of Traditional Chinese Medicine,Guangzhou
- Author bio：
- Funds：
- DOI：10.1007/BF02934192
  CLC：
- Published：1999，
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Manqi, X., Anzhong, L., Zhangzhi, Z. et al. Effects of supplemented Taohe Chengqi Decoction in treating insulin resistance in rats with non-insulin Dependent Diabetes Mellitus) in treating insulin resistance in rats with non-insulin Dependent Diabetes Mellitus., CJIM 5, 54–58 (1999). https://doi.org/10.1007/BF02934192

Xiong Manqi, Lin Anzhong, Zhu Zhangzhi, et al. Effects of supplemented Taohe Chengqi Decoction in treating insulin resistance in rats with non-insulin Dependent Diabetes Mellitus) in treating insulin resistance in rats with non-insulin Dependent Diabetes Mellitus. [J]. Chinese Journal of Integrative Medicine 5(1):54-58(1999)
Manqi, X., Anzhong, L., Zhangzhi, Z. et al. Effects of supplemented Taohe Chengqi Decoction in treating insulin resistance in rats with non-insulin Dependent Diabetes Mellitus) in treating insulin resistance in rats with non-insulin Dependent Diabetes Mellitus., CJIM 5, 54–58 (1999). https://doi.org/10.1007/BF02934192 DOI：

Xiong Manqi, Lin Anzhong, Zhu Zhangzhi, et al. Effects of supplemented Taohe Chengqi Decoction in treating insulin resistance in rats with non-insulin Dependent Diabetes Mellitus) in treating insulin resistance in rats with non-insulin Dependent Diabetes Mellitus. [J]. Chinese Journal of Integrative Medicine 5(1):54-58(1999) DOI： 10.1007/BF02934192.

摘要

Objective: To investigate the effect of supplemented Taohe Chengqi Decoction (

STHCQD) in treating non-insulin dependent diabetes mellitus (NIDDM).Methods: The model of rats with NIDDM was formed with injection of streptozotocin and fed on high calorie diet to study the effects of STHCQD on the release of insulin sensitivity.Results: (1) Fasting serum glucose

serum insulin

intake of food and water were significantly decreased (P < 0.05- 0.01) in STHCQD-treated diabetic rats as compared with untreated diabetic rats

while the insulin sensitivity was significantly increased (P < 0.05). (2) The liver cell membranes from STHCQD-treated diabetic rats released the quantity of insulin receptor which inhibited adenylate cyclase activity

but this effect was blunted in untreated diabetic rats (P < 0.05). (3) A significantly increased glucose oxidation in adipocyte of STHCQD-treated diabetic rats was found as compared with those of untreated diabetic rats (P < 0.05).Conclusions: STHCQD therapy increased sensitivity and responsiveness of target cells to insulin

i.e. it might decrease insulin resistance at receptor sites and post-receptor sites in rats with NIDDM

but could not reverse the insulin resistance.

Abstract

Objective: To investigate the effect of supplemented Taohe Chengqi Decoction (

serum insulin

intake of food and water were significantly decreased (P < 0.05- 0.01) in STHCQD-treated diabetic rats as compared with untreated diabetic rats

i.e. it might decrease insulin resistance at receptor sites and post-receptor sites in rats with NIDDM

but could not reverse the insulin resistance.

关键词

supplemented Taohe Chengqi Decoctionnon-insulin dependent diabetes mellitusinsulin resistanceinsulin mediatorglucose metabolismInsulin Sensitivity

Keywords

supplemented Taohe Chengqi Decoctionnon-insulin dependent diabetes mellitusinsulin resistanceinsulin mediatorglucose metabolismInsulin Sensitivity

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