Prevention of tumor necrosis factor-a induced insulin resistance by Radix Astragali

Lu Jin; Zou Dajin; Zhang Jiaqing

doi:10.1007/BF02934193

Your Location：

Home >

Browse articles >

Prevention of tumor necrosis factor-a induced insulin resistance by Radix Astragali

Updated：2021-08-27

- Prevention of tumor necrosis factor-a induced insulin resistance by Radix Astragali
- Chinese Journal of Integrative Medicine Vol. 5, Issue 1, Pages: 59-62(1999)
- Affiliations：
  
  Department of Endocrinology, Changhai Hospital, The Second Military Medical University,Shanghai
- Author bio：
- Funds：
- DOI：10.1007/BF02934193
  CLC：
- Published：1999，
Scan for full text
Jin, L., Dajin, Z. & Jiaqing, Z. Prevention of tumor necrosis factor-a induced insulin resistance by Radix Astragali., CJIM 5, 59–62 (1999). https://doi.org/10.1007/BF02934193

Lu Jin, Zou Dajin, Zhang Jiaqing. Prevention of tumor necrosis factor-a induced insulin resistance by Radix Astragali. [J]. Chinese Journal of Integrative Medicine 5(1):59-62(1999)
Jin, L., Dajin, Z. & Jiaqing, Z. Prevention of tumor necrosis factor-a induced insulin resistance by Radix Astragali., CJIM 5, 59–62 (1999). https://doi.org/10.1007/BF02934193 DOI：

Lu Jin, Zou Dajin, Zhang Jiaqing. Prevention of tumor necrosis factor-a induced insulin resistance by Radix Astragali. [J]. Chinese Journal of Integrative Medicine 5(1):59-62(1999) DOI： 10.1007/BF02934193.

摘要

Objective: To investigate the preventive effect of Radix Astragali on tumor necrosis factor-α (TNF-a) induced insulin resistance.Methods: Rats were treated orally with Radix Astragali before TNF-α intravenous injection. The changes of K value in glucose-insulin tolerance test

the concentrations of glucagon (GC)

ACTH and lipids in serum and the contents of glycogen

triglyceride (TG) in liver and red quadriceps were tested 4 hours after the injection and compared with the control.Results: Exogenous TNF-α can induce hyperinsulinemia in normal rats

and the K value decreased

the concentration of serum ACTH

GC and lipids all increased

the glycogen contents in liver and red quadriceps muscle decreased

and the liver TG depots increased. Radix Astragali can improve all the parameters significantly except the serum lipids level and liver triglyceride depots.Conclusions: Radix Astragali has preventive effect on insulin resistance induced by TNF-α and is useful in the treatment of type 2 diabetes. The mechanism may be due to the decrease of insulin-antagonistic hormones and the increase of tissue glycogen contents.

Abstract

the concentrations of glucagon (GC)

ACTH and lipids in serum and the contents of glycogen

triglyceride (TG) in liver and red quadriceps were tested 4 hours after the injection and compared with the control.Results: Exogenous TNF-α can induce hyperinsulinemia in normal rats

and the K value decreased

the concentration of serum ACTH

GC and lipids all increased

the glycogen contents in liver and red quadriceps muscle decreased

关键词

tumor necrosis factor-ainsulin resistanceRadix Astragalitype 2 diabetes

Keywords

tumor necrosis factor-ainsulin resistanceRadix Astragalitype 2 diabetes

references

Hotamisligil GS and Spiegelman BM. Tumor necrosis factorex: A key component of the obesity-diabetes link. Diabetes 1994; 43:1271–1278.

Leny J, Gavin III JR, Fausto A, et al. Impaired insulin action in rats with non-insulin-dependent diabetes. Diabetes 1984; 33:901–906.

Van Der Vies J. Two methods for the determination of glycogen in liver. Biochem J 1954; 57:410–416.

Storlien LH, Oakes ND, Pan DA, et al. Syndromes of insulin resistance in the rats: inducement by diet and amelioration with Benfluorex. Diabetes 1993; 42:457–462.

Lang CH, Dobrescu C, Bagby GJ. Tumor necrosis factor impairs insulin action on peripheral glucose disposal and hepatic glucose output. Endocrinology 1992; 130:43–52.

Van Der Poll T, Romijin JA, Endert E, et al. Tumor necrosis factor mimics the metabolic response to acute infection in healthy humans. Am J Physiol 1991; 261:E457-E465.

Peraldi P, Xu M, Spiegelman BM. Thiazolidinediones block tumor necrosis factor-alpha-induced inhibition of insulin signaling. J Clin Invest 1997; 100:1863–1869.

Morimoto Y, Nishikawa K and Ohashi M. KB-R7785, a novel matrix metalloproteinase inhibitor, exerts antidiabetic effect by inhibitory tumor necrosis factor-α production. Lif Sci 1997; 61:795–803.

Chin JE, Dicken M, Tavare JM, et al. Overexpression of protein kinase C isoenzymes α, βI, γ and ε in cells overexpressing the insulin receptor. J Biol Chem 1993; 268:6338–6347.

FULL TEXT LINK

More>

Views

353

Downloads

CSCD

Alert me when the article has been cited

Submit

Tools

Publicity Resources

Effects of royal jelly supplementation on glycemic control and oxidative stress factors in type 2 diabetic female: A randomized clinical trial

Liuwei Dihuang Pills (六味地黄丸) enhance the effect of Western medicine in treating type 2 diabetes: A meta-analysis of randomized controlled trials

Ping-tang Recipe (平糖方) improves insulin resistance and attenuates hepatic steatosis in high-fat diet-induced obese rats

Puerarin improve insulin resistance of adipocyte through activating Cb1 binding protein path

Progress in the research of Radix Astragali in treating chronic heart failure: Effective ingredients, dose-effect relationship and adverse reaction

Related Author

No data

Related Institution

Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz

Student Research Committee, Faculty of Nutrition, Tabriz University of Medical Sciences, Tabriz

Endocrinology Department of Medicine Faculty, Tabriz University of Medical Sciences, Tabriz

Nutrition Research Center, Tabriz University of Medical Sciences, Tabriz

Center for Healthcare Management Systems, East Carolina University

Address：1 Caochang, xiyuan, Beijing, People's Republic of China Postal code：100091
Tel：010-62886827, 62877592 Fax：010-62874291
Technical support is provided by Beijing Founder electronics co., LTD 京ICP备05067934号-1 京公网安备11010802024621
It is recommended to read the content of this site in Chrome&IE9+. Please switch to extreme mode in browser 360.
Cookies We use cookies to help provide and enhance our service and tailor content. By continuing, you agree to the use of cookies.

⁰