Effect of trichosanthin on cell cycle and apoptosis of murine melanoma cells

Bi Liqi; Li Hongjun; Zheng Deming

doi:10.1007/BF02934194

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Effect of trichosanthin on cell cycle and apoptosis of murine melanoma cells

Updated：2021-08-27

- Effect of trichosanthin on cell cycle and apoptosis of murine melanoma cells
- Chinese Journal of Integrative Medicine Vol. 5, Issue 1, Pages: 63-65(1999)
- Affiliations：
  
  The Third Teaching Hospital, Norman Bethune University of Medical Sciences,Changchun
- Author bio：
- Funds：
  
  Supported by the fund from National Natural Science Foundation of China (approved No. 39770913)
- DOI：10.1007/BF02934194
  CLC：
- Published：1999，
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Liqi, B., Hongjun, L. & Deming, Z. Effect of trichosanthin on cell cycle and apoptosis of murine melanoma cells., CJIM 5, 63–65 (1999). https://doi.org/10.1007/BF02934194

Bi Liqi, Li Hongjun, Zheng Deming. Effect of trichosanthin on cell cycle and apoptosis of murine melanoma cells. [J]. Chinese Journal of Integrative Medicine 5(1):63-65(1999)
Liqi, B., Hongjun, L. & Deming, Z. Effect of trichosanthin on cell cycle and apoptosis of murine melanoma cells., CJIM 5, 63–65 (1999). https://doi.org/10.1007/BF02934194 DOI：

Bi Liqi, Li Hongjun, Zheng Deming. Effect of trichosanthin on cell cycle and apoptosis of murine melanoma cells. [J]. Chinese Journal of Integrative Medicine 5(1):63-65(1999) DOI： 10.1007/BF02934194.

摘要

Objective: To study the inhibitory effect of purified trichosanthin component on the proliferation of malignant melanoma.Methods: The effect of purified trichosanthin component on the DNA synthesis

cell cycle and cell apoptosis of murine melanoma cells were detected by flow cytometry when cultured in vitro.Results: The significant G0/G1 phase arrest was revealed by the increase of cells in G0/G1 phase and decrease of cells in S phase. The obvious apoptosis of melanoma cells was induced by purified trichosanthin component. G0/ G1 phase arrest was highly correlated with apoptosis (r = 0. 8705).Conclusion: The purified trichosanthin component can markedly inhibit melanoma cells by the suppression of DNA synthesis in S phase and cell mitosis as well as induction of cell apoptosis.

Abstract

Objective: To study the inhibitory effect of purified trichosanthin component on the proliferation of malignant melanoma.Methods: The effect of purified trichosanthin component on the DNA synthesis

关键词

TrichosanthinMelanomaapoptosiscell cycleflowcytometry

Keywords

TrichosanthinMelanomaapoptosiscell cycleflowcytometry

references

Mayer RA, Sergios PA, Coonan K, et al. Trichosanthin treatment of HIV-induced immune dysregulation. Eur J Clin Invest 1992; 22(2): 113–122.

Wang QC, Ying WB, Xie H, et al. Trichosanthin-monoclonal antibody conjugate specially cytotoxic to human hepatoma cells in vitro. Cancer Res 1991; 51(13): 3353–3355.

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Carson DA, Ribeiro JM. Apoptosis and disease. Lancet 1993; 341(15): 1251–1254.

Song Q, Baxter GD, Kovacs EM, et al. Inhibition of apoptosis in human tumor cells by okadaic acid. J Cell Physiol 1992; 153(3): 550–556.

1994; 14(1): 18–20.

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