Effect of Astragalus Membranaceus on Ca2+ influx and CVB3 RNA replication in cultured neonatal rat heart cells infected with CVB3

Qi Guo; Tian-Qing Peng; Ying-Zhen Yang; Quan-Bao Gu; Jian-Xing Zhao

doi:10.1007/BF02934230

Your Location：

Home >

Browse articles >

Effect of Astragalus Membranaceus on Ca2+ influx and CVB3 RNA replication in cultured neonatal rat heart cells infected with CVB3

Updated：2021-08-27

- Effect of Astragalus Membranaceus on Ca2+ influx and CVB3 RNA replication in cultured neonatal rat heart cells infected with CVB3
- Chinese Journal of Integrative Medicine Vol. 2, Issue 1, Pages: 64-67(1996)
- Affiliations：
  
  1. Shanghai Institute of Cardiovascular Diseases, Zhong Shan Hospital of Shanghai Medical University,Shanghai
  2. Shanghai Institute of Cell Biology, Academia Sinica,Shanghai
- Author bio：
- Funds：
- DOI：10.1007/BF02934230
  CLC：
- Published：1996，
Scan for full text
Guo, Q., Peng, TQ., Yang, YZ. et al. Effect of Astragalus Membranaceus on Ca2+ influx and CVB3 RNA replication in cultured neonatal rat heart cells infected with CVB3., CJIM 2, 64–67 (1996). https://doi.org/10.1007/BF02934230

Qi Guo, Tian-Qing Peng, Ying-Zhen Yang, et al. Effect of Astragalus Membranaceus on Ca2+ influx and CVB3 RNA replication in cultured neonatal rat heart cells infected with CVB3. [J]. Chinese Journal of Integrative Medicine 2(1):64-67(1996)
Guo, Q., Peng, TQ., Yang, YZ. et al. Effect of Astragalus Membranaceus on Ca2+ influx and CVB3 RNA replication in cultured neonatal rat heart cells infected with CVB3., CJIM 2, 64–67 (1996). https://doi.org/10.1007/BF02934230 DOI：

Qi Guo, Tian-Qing Peng, Ying-Zhen Yang, et al. Effect of Astragalus Membranaceus on Ca2+ influx and CVB3 RNA replication in cultured neonatal rat heart cells infected with CVB3. [J]. Chinese Journal of Integrative Medicine 2(1):64-67(1996) DOI： 10.1007/BF02934230.

摘要

Here was investigated the effect of Radix Astragalus Membranaceus (AM) on Ca2+ influx across the myocardial plasma membrane and coxsackie virus B3(CVB3)-RNA replication in cultured neonatal rat heart cells infected with CVB3. It was found that the Ca2+ influx could be inhibited significantly by AM both in heart cells infected with CVB3 for 48 hours and in normal control heart cells. In addition

the Ca2+ influx and the amounts of CVB3-RNA in myocytes simultaneously infected with CVB3 and treated with AM for 48 hours were statistically decreased compared with that in CVB3-infected control cells. These phenomena suggested that AM could exert the effects of decreasing the secondary Ca2+ damages

improving the abnormal myocardial electric activity and inhibiting replication of CVB3-RNA in myocardium. Thus

it is a rational choice to treat patients with AM in viral myocarditis.

Abstract

improving the abnormal myocardial electric activity and inhibiting replication of CVB3-RNA in myocardium. Thus

it is a rational choice to treat patients with AM in viral myocarditis.

关键词

Coxsackie virus B3Viral MyocarditisCa2+ influxRadix Astragalus membranaceus

Keywords

Coxsackie virus B3Viral MyocarditisCa2+ influxRadix Astragalus membranaceus

references

Lawrence HC. Studies of virus-induced myocardial injury in mice: value of the acid mutation on different genetic backgrounds and combined with other mutations. Lab Animal Sci 1993; 43(2): 133.

Huber S, Polgar A, et al. T lymphocyte responses in CVB3-induced murine myocarditis. Scand J Infect Dis 1993; suppl 88: 67.

Tominage M, Matsumori A, Horie M, et al. Activation of Ca-permeable cation channels by myocarditis-associated antibody in guinea pig ventricular myocytes. J Clin Invest 1993; 91: 1231.

Yang Yz, Jin Py, Guo Q, et al. Treatment of experimental Coxsackie B3 viral myocarditis with Astragalus membranaceus in mice. Chin Med J 1990; 103(l): 14.

Rui T, Yang Yz Zhou Ts, et al. Effect of Astragalus membranaceus on electrophysiological activities of acute experimental Coxsackie B3 viral myocarditis in mice. Chin Med J 1993; 8: 203.

FULL TEXT LINK

More>

Views

739

Downloads

CSCD

Alert me when the article has been cited

Submit

Tools

Publicity Resources

Astragalus membranaceus Injection combined with conventional treatment for viral myocarditis: A systematic review of randomized controlled trials

Effects of Yiqi Huoxue Recipe (益气活血方) and Coxsackie virus B type 3 on the expression of ribosomal protein S20 in rat cardiac myocytes

Antiviral effects of aqueous extract from Spatholobus suberectus Dunn. against coxsackievirus B3 in mice

Observation on therapeutic effects of Shengmai powder in treating acute viral myocarditis

Effect of Astragalus Injection on levels of blood selenium and immunity function in children with viral myocarditis

Related Author

No data

Related Institution

Department of Traditional Chinese Medicine, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences

School of Oriental Medicine, Health Center, Life University, Marietta

Department of Traditional Chinese Medicine, Affiliated Hospital of Liaoning University of Traditional Chinese Medicine

Department of Environment and Health, Institute of Environmental and Health

Disease Prevention and Control Institute of the Chinese People’s Liberation Army

Address：1 Caochang, xiyuan, Beijing, People's Republic of China Postal code：100091
Tel：010-62886827, 62877592 Fax：010-62874291
Technical support is provided by Beijing Founder electronics co., LTD 京ICP备05067934号-1 京公网安备11010802024621
It is recommended to read the content of this site in Chrome&IE9+. Please switch to extreme mode in browser 360.
Cookies We use cookies to help provide and enhance our service and tailor content. By continuing, you agree to the use of cookies.

⁰