Effects of Qiwei Baizhu San in inhibiting replication of human rotavirus in vitro) in inhibiting replication of human rotavirus in vitro

Shuang-Teng He; Fei-Zhou He; Shun-Xiang Li; Shan Wang; Can-Rong Wu; Zheng-Wu Ou

doi:10.1007/BF02934232

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Effects of Qiwei Baizhu San in inhibiting replication of human rotavirus in vitro) in inhibiting replication of human rotavirus in vitro

Updated：2021-08-27

- Effects of Qiwei Baizhu San in inhibiting replication of human rotavirus in vitro) in inhibiting replication of human rotavirus in vitro
- Chinese Journal of Integrative Medicine Vol. 2, Issue 1, Pages: 68-71(1996)
- Affiliations：
  
  1. Hunan Academy of Traditional Chinese Medicine,Changsha
  2. Hunan College of Traditional Chinese Medicine,Changsha
- Author bio：
- Funds：
- DOI：10.1007/BF02934232
  CLC：
- Published：1996，
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He, ST., He, FZ., Li, SX. et al. Effects of Qiwei Baizhu San in inhibiting replication of human rotavirus in vitro) in inhibiting replication of human rotavirus in vitro., CJIM 2, 68–71 (1996). https://doi.org/10.1007/BF02934232

Shuang-Teng He, Fei-Zhou He, Shun-Xiang Li, et al. Effects of Qiwei Baizhu San in inhibiting replication of human rotavirus in vitro) in inhibiting replication of human rotavirus in vitro. [J]. Chinese Journal of Integrative Medicine 2(1):68-71(1996)
He, ST., He, FZ., Li, SX. et al. Effects of Qiwei Baizhu San in inhibiting replication of human rotavirus in vitro) in inhibiting replication of human rotavirus in vitro., CJIM 2, 68–71 (1996). https://doi.org/10.1007/BF02934232 DOI：

Shuang-Teng He, Fei-Zhou He, Shun-Xiang Li, et al. Effects of Qiwei Baizhu San in inhibiting replication of human rotavirus in vitro) in inhibiting replication of human rotavirus in vitro. [J]. Chinese Journal of Integrative Medicine 2(1):68-71(1996) DOI： 10.1007/BF02934232.

摘要

Qiwei Baizhu San was found to have an inhibitory effect on human rotavirus at monolayers of MA104 cells. A 50% reduction in plaque number

a 101.86 TCID50 decrease in viral replication index and an around 60% inhibition in viral RNA synthesis were observed at concentration of 100 mg/ml. Furthermore

the cytotoxicity of the decoction was low

while its promoting effect on growth and proliferation of the culture cells was observed at the concentrations of 12.5~50 mg/ml. The decoction was also found to have effects in prolonging the survival time of infected cells with rotavirus and promoting the regeneration of the infected cells.

Abstract

Qiwei Baizhu San was found to have an inhibitory effect on human rotavirus at monolayers of MA104 cells. A 50% reduction in plaque number

a 101.86 TCID50 decrease in viral replication index and an around 60% inhibition in viral RNA synthesis were observed at concentration of 100 mg/ml. Furthermore

the cytotoxicity of the decoction was low

关键词

Human rotavirusQiwei Baizhu Santissue cultureantiviral activity

Keywords

Human rotavirusQiwei Baizhu Santissue cultureantiviral activity

references

WHO Scientific Working Group. Rotavirus and otherviral diarrheas. Bull WHO 1980; 58: 183 - 198.

Vaughan VC. Nelson’s text book of pediatrics, ed 11. Philadelphia: Saunders, 1979: 1072 - 1075.

Sato K, Ihaba Y, Shinzuka T, et al. Isolation ofhuman ro-tavirua in cell cultures. Arch Virol 1981; 69: 155 - 160.

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Department of Biosynthesis, School of Pharmacy, Fudan University

Institute of Chinese Medicine, Tongji University

Shanghai Medical College, Fudan University

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