Effect of Shenmai injection on immunologic function in stomach cancer patients after chemotherapy) on immunologic function in stomach cancer patients after chemotherapy

Sheng-You Lin; Lu-Ming Liu; Liang-Cun Wu; Wei-Shun Zhou; Yong Guo; Min-He Shen; Wei-Hong Yang; Chang-Sheng Xie; Liang-Liang Chen; Pei-Fang Feng

doi:10.1007/BF02934248

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Effect of Shenmai injection on immunologic function in stomach cancer patients after chemotherapy) on immunologic function in stomach cancer patients after chemotherapy

Updated：2021-08-27

- Effect of Shenmai injection on immunologic function in stomach cancer patients after chemotherapy) on immunologic function in stomach cancer patients after chemotherapy
- Chinese Journal of Integrative Medicine Vol. 2, Issue 3, Pages: 195-197(1996)
- Affiliations：
  
  Zhejiang Provincial Hospital of TCM,Hangzhou
- Author bio：
- Funds：
- DOI：10.1007/BF02934248
  CLC：
- Published：1996，
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Lin, SY., Liu, LM., Wu, LC. et al. Effect of Shenmai injection on immunologic function in stomach cancer patients after chemotherapy) on immunologic function in stomach cancer patients after chemotherapy., CJIM 2, 195–197 (1996). https://doi.org/10.1007/BF02934248

Sheng-You Lin, Lu-Ming Liu, Liang-Cun Wu, et al. Effect of Shenmai injection on immunologic function in stomach cancer patients after chemotherapy) on immunologic function in stomach cancer patients after chemotherapy. [J]. Chinese Journal of Integrative Medicine 2(3):195-197(1996)
Lin, SY., Liu, LM., Wu, LC. et al. Effect of Shenmai injection on immunologic function in stomach cancer patients after chemotherapy) on immunologic function in stomach cancer patients after chemotherapy., CJIM 2, 195–197 (1996). https://doi.org/10.1007/BF02934248 DOI：

Sheng-You Lin, Lu-Ming Liu, Liang-Cun Wu, et al. Effect of Shenmai injection on immunologic function in stomach cancer patients after chemotherapy) on immunologic function in stomach cancer patients after chemotherapy. [J]. Chinese Journal of Integrative Medicine 2(3):195-197(1996) DOI： 10.1007/BF02934248.

摘要

Sixty-three cases with stomach cancer were randomized into 2 groups and observed

the results showed that the count of T lymphocytes in chemotherapy combined with Shenmai injection (SMI) group increased

while in the control group it decreased

the difference being quite significant (P<0.05). The results also showed that the count of OKT1 cells and the OKT4/OKT8 ratio decreased after chemotherapy

but in SMI group both parameters increased in advance

which were higher in the 4th week after chemotherapy than that before chemotherapy. However in the meantime

the count of OKT1 cells and OKT4/OKT8 ratio of control group were still in low level. After chemotherapy the serum interleukin-2 receptor (sIL-2R) level also decreased (P<0.05)

while activities of natural killer cell (NK) and lymphokine activated killer cell (LAK) level increased (P<0.05) in SMI group. But in the control group

although the sIL-2R level had no change

both NK and Lak level decreased significantly (P<0.05). In addition

the difference of IgA

IgM

IgG levels was not significant between these two groups. These results suggested that SMI might improve human immunologic function to facilitate the chemotherapy of patients with stomach cancer.

Abstract

Sixty-three cases with stomach cancer were randomized into 2 groups and observed

the results showed that the count of T lymphocytes in chemotherapy combined with Shenmai injection (SMI) group increased

while in the control group it decreased

the difference being quite significant (P<0.05). The results also showed that the count of OKT1 cells and the OKT4/OKT8 ratio decreased after chemotherapy

but in SMI group both parameters increased in advance

which were higher in the 4th week after chemotherapy than that before chemotherapy. However in the meantime

the count of OKT1 cells and OKT4/OKT8 ratio of control group were still in low level. After chemotherapy the serum interleukin-2 receptor (sIL-2R) level also decreased (P<0.05)

while activities of natural killer cell (NK) and lymphokine activated killer cell (LAK) level increased (P<0.05) in SMI group. But in the control group

although the sIL-2R level had no change

both NK and Lak level decreased significantly (P<0.05). In addition

the difference of IgA

IgM

IgG levels was not significant between these two groups. These results suggested that SMI might improve human immunologic function to facilitate the chemotherapy of patients with stomach cancer.

关键词

Shenmai injectionstomach cancerchemotherapytumor immunity

Keywords

Shenmai injectionstomach cancerchemotherapytumor immunity

references

T 1986;9(4):215.

T A 1987:7(2):79.

Robinson E, Segal R, Vesely Z, et al. Lymphocyte subpopulations in peripheral blood and malignant effusions of cancer patients. Eur J Cancer Clin Oncol 1986; 22:191.

OKT (SLE) T 1985;5(3):156.

Laurence A. The soluble IL-2 receptor biology, function and clinical application. Annals of Internal Medicine 1990; 113: 619.

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