Influence of Qingdai Compound Capsule on the expression of c-myc in psoriatic keratinocytes) on the expression of c-myc in psoriatic keratinocytes

Jie Feng; Han-Qing Xu; Bao-Shan Su

doi:10.1007/BF02934249

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Influence of Qingdai Compound Capsule on the expression of c-myc in psoriatic keratinocytes) on the expression of c-myc in psoriatic keratinocytes

Updated：2021-08-27

- Influence of Qingdai Compound Capsule on the expression of c-myc in psoriatic keratinocytes) on the expression of c-myc in psoriatic keratinocytes
- Chinese Journal of Integrative Medicine Vol. 2, Issue 3, Pages: 198-200(1996)
- Affiliations：
  
  Department of Dermatology, The Second Affiliated Hospital, Xi’an Medical University,Xi’an
- Author bio：
- Funds：
- DOI：10.1007/BF02934249
  CLC：
- Published：1996，
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Feng, J., Xu, HQ. & Su, BS. Influence of Qingdai Compound Capsule on the expression of c-myc in psoriatic keratinocytes) on the expression of c-myc in psoriatic keratinocytes., CJIM 2, 198–200 (1996). https://doi.org/10.1007/BF02934249

Jie Feng, Han-Qing Xu, Bao-Shan Su. Influence of Qingdai Compound Capsule on the expression of c-myc in psoriatic keratinocytes) on the expression of c-myc in psoriatic keratinocytes. [J]. Chinese Journal of Integrative Medicine 2(3):198-200(1996)
Feng, J., Xu, HQ. & Su, BS. Influence of Qingdai Compound Capsule on the expression of c-myc in psoriatic keratinocytes) on the expression of c-myc in psoriatic keratinocytes., CJIM 2, 198–200 (1996). https://doi.org/10.1007/BF02934249 DOI：

Jie Feng, Han-Qing Xu, Bao-Shan Su. Influence of Qingdai Compound Capsule on the expression of c-myc in psoriatic keratinocytes) on the expression of c-myc in psoriatic keratinocytes. [J]. Chinese Journal of Integrative Medicine 2(3):198-200(1996) DOI： 10.1007/BF02934249.

摘要

In this immunohistochemical study

the authors detected the expression of c-myc in keratinocytes (ECK) from 30 psoriatics before and after Qingdai Compound Capsule (QDCC) treatment and 12 normal subjects for control. The results showed that the ECK of patients before treatment was significantly higher than that in the normal control group

and its level was correlated with histopathological changes of affected skin. After treatment the ECK was normalized. It is believed that QDCC could decrease the ECK in psoriatics and this effect was probably mediated by inhibiting c-myc expression. This study provided an experimental evidence for the application of QDCC in treating psoriasis.

Abstract

In this immunohistochemical study

关键词

Qingdai compound capsulekeratinocyte c-mycimmunohistochemical examinationpsoriasis

Keywords

Qingdai compound capsulekeratinocyte c-mycimmunohistochemical examinationpsoriasis

references

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Elefthriades EG, Boumpas DT, Balow JE, et al. Transcriptional and posttranscription responsible for the increase expression of c-myc protooncogene in lymphocytes from patients with systemic lupus erythematosus. Clin Immunol Immunolpathol 1989; 52:507–518.

Kelly K, Sochran BH, Stiles CD, et al. Cell specific regulation of the c-myc gene by lymphocyte mitogens and platelet derived growth fator. Cell 1983; 35:603 - 609.

Barbara S Baker, Lionel Fry. The immunology of psoriasis. B J Dermatol 1992; 126:1–7.

Williams RC Jr, Sibbitt WL Jr, Husby G. Oncogenes, viruses, of rheumogenes. Am J Med 1986; 80: 1011–1018.

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