Clinical study on protective effect of ginaton on ischemia-reperfusion injured myocardium during cardiopulmonary bypass

Yun-kun Deng; Zheng-lun Li; Tian-hai Shen; Shi-yu Yang; Xing-zhi Yan; Da-guo Zhang; Xiu-lun Liu

doi:10.1007/BF02934301

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Clinical study on protective effect of ginaton on ischemia-reperfusion injured myocardium during cardiopulmonary bypass

Updated：2021-08-27

- Clinical study on protective effect of ginaton on ischemia-reperfusion injured myocardium during cardiopulmonary bypass
- Chinese Journal of Integrative Medicine Vol. 8, Issue 3, Pages: 172-174(2002)
- Affiliations：
  
  Anesthesia Department, Guizhou Provincial People’s Hospital,Guiyang
- Author bio：
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- DOI：10.1007/BF02934301
  CLC：
- Published：2002，
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Deng, Yk., Li, Zl., Shen, Th. et al. Clinical study on protective effect of ginaton on ischemia-reperfusion injured myocardium during cardiopulmonary bypass., CJIM 8, 172–174 (2002). https://doi.org/10.1007/BF02934301

Yun-kun Deng, Zheng-lun Li, Tian-hai Shen, et al. Clinical study on protective effect of ginaton on ischemia-reperfusion injured myocardium during cardiopulmonary bypass. [J]. Chinese Journal of Integrative Medicine 8(3):172-174(2002)
Deng, Yk., Li, Zl., Shen, Th. et al. Clinical study on protective effect of ginaton on ischemia-reperfusion injured myocardium during cardiopulmonary bypass., CJIM 8, 172–174 (2002). https://doi.org/10.1007/BF02934301 DOI：

Yun-kun Deng, Zheng-lun Li, Tian-hai Shen, et al. Clinical study on protective effect of ginaton on ischemia-reperfusion injured myocardium during cardiopulmonary bypass. [J]. Chinese Journal of Integrative Medicine 8(3):172-174(2002) DOI： 10.1007/BF02934301.

摘要

To observe the myocardial protecting effects of Ginaton (Ginkgo biloba extract) on ischemic-reperfusion injured myocardium during cardiopulmonary bypass (CPB). Twenty patients selected undergoing mitral valvular replacement were randomly divided into two groups. Control group: 10 patients

intermittent intra-aortic infusion with cold St. Thomas solution during hypothermic CPB. Ginaton group: 10 patients

intermittent intra-aortic infusion with cold St. Thomas solution containing Ginaton (0.5 mg’kg1). Changes of ultrastructure levels of adenosine triphosphate (ATP)

malondialdehyde (MDA) and hemodynamic data were measured. Hemodynamic parameters in the Ginaton group were maintained better than those in the control group. MDA in the control group was significantly elevated during ischemic-reperfusion (P<0.05)

while in the Ginaton group

there were no obvious change. The levels of ATP and energy change in the Ginaton group were obviously higher than those in the control group at declamping aorta (P< 0. 05). The percentage of normal mitochondria and glycogen content were significantly higher in the Ginaton group than that in the control group at declamping aorta (P< 0.05). Ginkgo biloba extract may provide a beneficial effect on myocardial protection in ultrastructural preservation

prevention of high energy phosphate depletion

reduction in free radicals production and improvement of myocardial function.

Abstract

intermittent intra-aortic infusion with cold St. Thomas solution during hypothermic CPB. Ginaton group: 10 patients

intermittent intra-aortic infusion with cold St. Thomas solution containing Ginaton (0.5 mg’kg1). Changes of ultrastructure levels of adenosine triphosphate (ATP)

while in the Ginaton group

prevention of high energy phosphate depletion

reduction in free radicals production and improvement of myocardial function.

关键词

Ginkgo Biloba Extractischemic-reperfusion injurymyocardial protection

Keywords

Ginkgo Biloba Extractischemic-reperfusion injurymyocardial protection

references

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Deng YK, Yu ZH, Yu T, et al. The heart protection effect of GBL extract St. Thomas solution. Chin J Anesth 1999;19(2):116–117.

Wynants J, Belle HV. Single-run performance liquid chromatography of nucleotides, nucleosides and major purine bases and its application to different tissue extracts. Anal Biochem 1985; 144:258–266.

Yu ZH, Cong LK, Li WC, et al. Study on large dosage of insulin to elevate the myocardium protection effect. Chin J Anesth 1987;7(1):5–10.

Punkt K, Welt K, Schaffranietz L. Changes of enzyme activities in the rat myocardium caused experimental hypoxia with and without Ginkgo biloba extract EGB761 pretreatment. A Cytophotometrical study. Acta Histochem 1995; 97: 67–69.

Koltai M, Tosaki A, Hosford D, et al. Ginkgolide B protects isolated hearts against arrhythmia induced by ischemia but not reperfusion. Eur J Pharmacol 1989; 164:293–302.

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Related Institution

Department of Stomatology, Beijing Chaoyang Hospital, Capital Medical University

Department of Infectious Diseases and Clinical Microbiology, Beijing Chaoyang Hospital, Beijing Institute of Respiratory Medicine, Capital Medical University

Department of Microbiology, Capital Medical University

Department of Anesthesiology, Sun Yat-sen University Tungwah Hospital

Department of Anesthesiology, The First Affiliated Hospital, Chongqing University of Medical Sciences

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