To observe the effects of Ixeris sonchifolia Hance (ISH) on platelet function and hemorrheology in type 2 diabetes mellitus (DM) patients. Thirty-three type 2 DM patients were treated with 20 ml ISH per day

intravenously dripping for 15 days; 31 patients in the red sage treated group were treated with composite red sage injection intravenous dripping for 15 days

and their changes of platelet membrane glycoprotein П b/Ш a compound (GPП b/Шa)

granular membrane protein-140 (GMP-140)

platelet aggregation rate (PAgR) and hemorrheology were observed. After treatment with ISH

the GPП b/Ш a compound positive rate of 33 type 2 DM patients were lowered (P< 0.05)

GMP-140 showed lowering trend

PAgR obviously reduced

and compared with before treatment it showed significant difference; comparison between the two groups after treatment

it showed significant difference (P < 0. 05

P < 0. 01). At the same time

the various parameters of hemorrheology displayed significant improvement. There was no adverse effect during the course of treatment. ISH could improve platelet function and abnormal hemorrheology of type 2 DM patients

which is vital for the treatment of DM and their vascular lesion.