Effect of yiqi jianpi bushen recipe in reducing nephrotoxicity of cisplatin

LU Kong; Xi-wei Zhou; EN Li; Wei-Jian Feng; Zan Sheng; Jing-zhi He

doi:10.1007/BF02934307

Your Location：

Home >

Browse articles >

Effect of yiqi jianpi bushen recipe in reducing nephrotoxicity of cisplatin

Updated：2021-08-27

- Effect of yiqi jianpi bushen recipe in reducing nephrotoxicity of cisplatin
- Chinese Journal of Integrative Medicine Vol. 8, Issue 3, Pages: 191-194(2002)
- Affiliations：
  
  1. Department of Biochemistry, Hebei Medical University,Shijiazhuang
  2. Chemotherapy Department, The Fourth Hospital of Hebei Medical University,China
  3. Department of Immunology, Hebei Medical University,China
- Author bio：
- Funds：
- DOI：10.1007/BF02934307
  CLC：
- Published：2002，
Scan for full text
Kong, L., Zhou, Xw., Li, E. et al. Effect of yiqi jianpi bushen recipe in reducing nephrotoxicity of cisplatin., CJIM 8, 191 (2002). https://doi.org/10.1007/BF02934307

LU Kong, Xi-wei Zhou, EN Li, et al. Effect of yiqi jianpi bushen recipe in reducing nephrotoxicity of cisplatin. [J]. Chinese Journal of Integrative Medicine 8(3):191-194(2002)
Kong, L., Zhou, Xw., Li, E. et al. Effect of yiqi jianpi bushen recipe in reducing nephrotoxicity of cisplatin., CJIM 8, 191 (2002). https://doi.org/10.1007/BF02934307 DOI：

LU Kong, Xi-wei Zhou, EN Li, et al. Effect of yiqi jianpi bushen recipe in reducing nephrotoxicity of cisplatin. [J]. Chinese Journal of Integrative Medicine 8(3):191-194(2002) DOI： 10.1007/BF02934307.

摘要

To observe the clinical effect of Yiqi Jianpi Bushen recipe (YQJPBS

) in antagonizing nephrotoxicity and hematological toxicity by cisplatin (CDDP). The patients with different types of carcinomas were divided into two groups. One group was treated by western medicine (WM)

i.e. cisplatin combined with diuretic therapy. The other group by Chinese medicine (CM). One day before chemotherapy

YQJPBS was given orally. Urinary enzyme (NAG

Y-GT

ALP) and serum erythropoietin (Epo) were used as the key monitoring indicator. The early renal damage by CDDP remains near proximal convoluted tubule

which leads to the rising of urinary enzyme. So urinary enzyme of the CM group was obviously lower than that of the WM group. The lesion of renal interstitial cells that produce Epo did not cause the serum Epo of WM group to rise obviously 15 days later. As a result there was 40% patients whose RBC and Hb became lower than the standard count. While serum Epo of CM group was higher than that of WM group

only 5% patients in the CM group had their RBC and Hb lowered. YQJPBS can effectively antagonize nephrotoxicity and hematological toxicity induced by CDDP.

Abstract

To observe the clinical effect of Yiqi Jianpi Bushen recipe (YQJPBS

i.e. cisplatin combined with diuretic therapy. The other group by Chinese medicine (CM). One day before chemotherapy

YQJPBS was given orally. Urinary enzyme (NAG

Y-GT

ALP) and serum erythropoietin (Epo) were used as the key monitoring indicator. The early renal damage by CDDP remains near proximal convoluted tubule

only 5% patients in the CM group had their RBC and Hb lowered. YQJPBS can effectively antagonize nephrotoxicity and hematological toxicity induced by CDDP.

关键词

Yiqi Jianpi Bushen recipecisplatinnephrotoxicityurinary enzymeerythropoietin

Keywords

Yiqi Jianpi Bushen recipecisplatinnephrotoxicityurinary enzymeerythropoietin

references

Gao LP, Li E. Experimental study on the mechanism in rat anemia by cisplatin and effect of the Chinese medicine. Chin J Basic Med TCM 1996;2(3): 38–42.

Li WJ, Zheng YX, Li YF, et al. Pharmacokinetics of carboplatin and cisplatin in rat. Chin J Pharmaceut 1991; 22:220–223.

Fan YP. Nephrotoxicity of anti-tumor drugs. Foreign Medical Sciences (Fascicle of Endocrinology) 1991 ;8: 397–399.

Wang LW, Zhang SW, Yang T, et al. Nephrotoxicity of cisplatin. ACTA Pharmacol Sinica 1987; 8: 166 -169.

Fox JG, Kerr DJ, Soukop M, et al. Successful use of cisplatin to treat metastatic seminoma during cisplatin-induced acute renal failure. Cancer 1991;68:1720–1732.

Satoh M, Naganuma A, Imura N. Optimum schedule of selenium administration to reduce lethal and renal toxicities of cis-diaminedichloroplatinum (cis-DDP) in mice. J Pharmacobiodyn 1989;12(4):246.

Qiu XF, Li ZX. Clinical observation and experimental study in nephrotoxicity of cisplatin. Chin J Obst Gynecol 1992;27:35–37.

Wang DG, Wang LW, Yang T, et al. Prevention of selenium for nephrotoxicity by cisplatin. Chin J Pharmacol Toxicol 1990;4:293–297.

Ye ZG. The effect of Shiquan Dabu decoction reducing tonic side-effects by cisplatin. Foreign Medical Sciences TCM Fascicle 1997; 15(2): 7–9.

Cascinu S, Fedeli A, Luzi Fedeli S, et al. Cisplatin associated anemia treated with subcutaneous erythropoietin. A pilot study. Br J Cancer 1993;67:156–158.

Saito Y, Mori K, Tomminaga K, et al. Phase II study of 5-day continuous infusion of cis-diaminodichloroplatinum (II) in the treatment non-small-cell lung cancer. Cancer Chemother Pharmacol 1990; 26:389–392.

Miller CB, Platanias LC, Mills SR, et al. Phase I-II trial of erythropoietin in the treatment of cisplatin-associated anemia. J Nat Cane Inst 1992;84:98–103.

Wood P, Hrushesky WJM. Cisplatin-induced anemia: an erythropoietin deficiency. Proc Am Soc Clin Oncol 1984;3: 22.

Bray GL, Reaman GH. Erythropoietin deficiency: a complication of cisplatin therapy and its treatment with recombinant human erythropoietin. Am J Pediatr Hematol Oncol 1991; 13:426–430.

Hase Gawa I and Tanaka K. Serum erythropoietin levels in gynecologic cancer patients during cisplatin combination chemotherapy. Gynecol Oncol 1992; 46:65–68.

Platanias LC, Miller CB, Mick R, et al. Treatment of chemotherapy-induced anemia with recombinant human erythropoietin in cancer patients. J Clin Oncol 1991; 9: 2021–2026.

Smith DH, Goldwasser E, Voks EE. Serum immunoerythropoietin levels in patients with cancer receiving cisplatinbased chemotherapy. Cancer 1991;68:1101–1105.

Auoteng SZ. Chinese medicine and treatment for tumor. New Drug Clinic 1996;45(7):3–7.

FULL TEXT LINK

More>

Views

373

Downloads

CSCD

Alert me when the article has been cited

Submit

Tools

Publicity Resources

Apoptotic effect of cisplatin and cordycepin on OC3 human oral cancer cells

Clinical observation on the efficacy of Xiaoshui decoction (消水方) combined with intrapleural perfusion of cisplatin in treating malignant pleural effusion

Improvement of quality of life with Shenfu injection in non small cell lung cancer patients treated with gemcitabine plus cisplatin regimen

Effect of combination of Bushen Jianpi Recipe and erythropoietin on serum tumor necrosis factor a in patients with anemia

Protective effect of Shengmai Injection on rats with contrast medium-associated acute renal failure) on rats with contrast medium-associated acute renal failure

Related Author

No data

Related Institution

Department of Cell Biology and Anatomy, and College of Medicine, National Cheng Kung University, Tainan

Department of Food Science and Technology, College of Human Ecology, HungKuang University, Taichung

Institute of Hot Spring Industry, Chia Nan University of Pharmacy and Science, Tainan

Department of Anesthesiology, Chang Gung Memorial Hospital and Kaohsiung Medical Center, Chang Gung University, Kaohsiung

Division of Endocrinology and Metabolism, Kaohsiung Veteran General Hospital Tainan Branch, Tainan

Address：1 Caochang, xiyuan, Beijing, People's Republic of China Postal code：100091
Tel：010-62886827, 62877592 Fax：010-62874291
Technical support is provided by Beijing Founder electronics co., LTD 京ICP备05067934号-1 京公网安备11010802024621
It is recommended to read the content of this site in Chrome&IE9+. Please switch to extreme mode in browser 360.
Cookies We use cookies to help provide and enhance our service and tailor content. By continuing, you agree to the use of cookies.

⁰