Experimental study on effect of renal failure granule in treating uremia

Chen Wang; Ping-dong Zheng; Li-qun He; Yi Wang

doi:10.1007/BF02934312

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Experimental study on effect of renal failure granule in treating uremia

Updated：2021-08-27

- Experimental study on effect of renal failure granule in treating uremia
- Chinese Journal of Integrative Medicine Vol. 8, Issue 3, Pages: 208-211(2002)
- Affiliations：
  
  Shuguang Hospital Affiliated to Shanghai University of Traditional, Chinese Medicine,Shanghai
- Author bio：
- Funds：
- DOI：10.1007/BF02934312
  CLC：
- Published：2002，
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Wang, C., Zheng, Pd., He, Lq. et al. Experimental study on effect of renal failure granule in treating uremia., CJIM 8, 208–211 (2002). https://doi.org/10.1007/BF02934312

Chen Wang, Ping-dong Zheng, Li-qun He, et al. Experimental study on effect of renal failure granule in treating uremia. [J]. Chinese Journal of Integrative Medicine 8(3):208-211(2002)
Wang, C., Zheng, Pd., He, Lq. et al. Experimental study on effect of renal failure granule in treating uremia., CJIM 8, 208–211 (2002). https://doi.org/10.1007/BF02934312 DOI：

Chen Wang, Ping-dong Zheng, Li-qun He, et al. Experimental study on effect of renal failure granule in treating uremia. [J]. Chinese Journal of Integrative Medicine 8(3):208-211(2002) DOI： 10.1007/BF02934312.

摘要

To observe the efficacy of Renal Failure Granule (RFG) in treating uremia and explore its mechanism. Piatt’s method was used to establish the chronic renal failure model. Forty-eight rats were divided into normal group

model group

Jiangzhuo recipe group

Fuzheng recipe group

RFG group and aldehyde-oxygen encapsulated starch group

8 rats in each group

to observe the effects of RFG on serum creatinine (SCr)

blood urea nitrogen (BUN)

plasma calcium (Ca)

plasma phosphorus (P)

parathyroid hormone (PTH)

middle molecular substance (MMS)

methylguanidine (MG)

guanidino-succinic acid (GSA) and other parameters. Comparison of SCr and BUN changes after medication for 30 and 60 days

the RFG group

the Fuzheng recipe group and the Jiangzhuo recipe group

with the aldehyde-oxygen encapsulated starch group or model group

demonstrated that the difference was significant (P<0.05

P<0.01)

For PTH

MMS

MG and GSA

RFG was clearly different with the model group (P<0.05

P<0.01). Jiangzhuo recipe and Fuzheng recipe group also were variously efficacious in above-mentioned parameters. RFG can retard the development of uremia

and its mechanism may be related to the decrease of uremic toxin.

Abstract

model group

Jiangzhuo recipe group

Fuzheng recipe group

RFG group and aldehyde-oxygen encapsulated starch group

8 rats in each group

to observe the effects of RFG on serum creatinine (SCr)

blood urea nitrogen (BUN)

plasma calcium (Ca)

plasma phosphorus (P)

parathyroid hormone (PTH)

middle molecular substance (MMS)

methylguanidine (MG)

guanidino-succinic acid (GSA) and other parameters. Comparison of SCr and BUN changes after medication for 30 and 60 days

the RFG group

the Fuzheng recipe group and the Jiangzhuo recipe group

with the aldehyde-oxygen encapsulated starch group or model group

demonstrated that the difference was significant (P<0.05

P<0.01)

For PTH

MMS

MG and GSA

RFG was clearly different with the model group (P<0.05

P<0.01). Jiangzhuo recipe and Fuzheng recipe group also were variously efficacious in above-mentioned parameters. RFG can retard the development of uremia

and its mechanism may be related to the decrease of uremic toxin.

关键词

uremiaRenal Failure Granuletoxin

Keywords

uremiaRenal Failure Granuletoxin

references

Platt R, Roscoe MH, Smith FW. Experimental renal failure. Clin Sci 1952; 11: 217–231.

Zheng Pingdong. A study on the action of a modified wen-pi-tang prescription, using uremic toxins in blood as indices. Phytotherapy Research 1994; 3 (2): 26–27.

Ageta T, Sugino BZ. Renal insufficiency. Tokyo: Tokyo Medical Press, 1977: 88.

Xu PX. Current status of middle molecular substance. Bio-chem Commun 1988; (3): 28–30.

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Faculty of Orthopedics and Traumatology, Fujian College of TCM

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