Study on treatment of primary hepatic carcinoma by arterial perfusion embolization with zedoary turmeric oil

Jian-hua Cheng; Gang Chang; Wan-yin Wu; Wei-sheng Liu; Zhi-gang Yang; Fan-zhe Meng; Kai Xu; Liu-ning Li; Di-ying Zhu; Chun-yong Chen; Hai-ying Luo

doi:10.1007/BF02934366

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Study on treatment of primary hepatic carcinoma by arterial perfusion embolization with zedoary turmeric oil

Updated：2021-08-27

- Study on treatment of primary hepatic carcinoma by arterial perfusion embolization with zedoary turmeric oil
- Chinese Journal of Integrative Medicine Vol. 7, Issue 4, Pages: 261-267(2001)
- Affiliations：
  
  Guangdong Provincial Hospital of TCM,Guangzhou
- Author bio：
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- DOI：10.1007/BF02934366
  CLC：
- Published：2001，
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Cheng, Jh., Chang, G., Wu, Wy. et al. Study on treatment of primary hepatic carcinoma by arterial perfusion embolization with zedoary turmeric oil., CJIM 7, 261–267 (2001). https://doi.org/10.1007/BF02934366

Jian-hua Cheng, Gang Chang, Wan-yin Wu, et al. Study on treatment of primary hepatic carcinoma by arterial perfusion embolization with zedoary turmeric oil. [J]. Chinese Journal of Integrative Medicine 7(4):261-267(2001)
Cheng, Jh., Chang, G., Wu, Wy. et al. Study on treatment of primary hepatic carcinoma by arterial perfusion embolization with zedoary turmeric oil., CJIM 7, 261–267 (2001). https://doi.org/10.1007/BF02934366 DOI：

Jian-hua Cheng, Gang Chang, Wan-yin Wu, et al. Study on treatment of primary hepatic carcinoma by arterial perfusion embolization with zedoary turmeric oil. [J]. Chinese Journal of Integrative Medicine 7(4):261-267(2001) DOI： 10.1007/BF02934366.

摘要

To evaluate the effect

side-effect and prospect of hepatic arterial perfusion embolization (HAPE) with Zedoary turmeric oil (ZTO) in treating primary hepatic carcinoma (PHC). Clinical study was carried out by administration of 1/2-3 ml ZTO through arterial catheter to induce embolism in 32 patients of PHC

and compared with 32 patients treated by hepatic arterial perfusion embolization with chemical agents (HAPE-C) in the control group. The Chinese herbal medicine was given orally to both groups according to Syndrome Differentiation of TCM. In the experimental study

transplantation hepatic carcinoma model was established in 40 rats. They were randomly divided into the treated group and the control group

20 in each group

and were perfused with 10 mg/kg ZTO and 0.2/2-0.3 ml normal saline respectively to observe the effect of treatment. The effect of treatment in the ZTO group was CR in 1 case and PR in 13 cases

the total effective rate being 43.75%

with AFP negative reversed in 7 cases

titer decreased in 7; while in the control group it was PR in 10 cases

the total effective rate being 31. 25%

AFP negative reversed in 5

titer decreased in 2

and the difference of therapeutic effect between the two groups was insignificant (P>0.05). The post-perfusion thrombotic syndrome occurrence

with the symptoms of fever

abdominal pain

vomiting

etc. in the two groups was similar

but no bone marrow inhibition occurred in the ZTO group

which was different from the control group (P<0. 01

P<0.05). The mean survival time

median survival time

3- and 4-year survival rate in the ZTO group was 13.84 months

10 months

37.5%

18.87%

9.70% and 6.4% respectively

and in the control group

8.03 months

6 months

15.6%

6. 27%

0% and 0% respectively

the mean survival time

median survival time and 1-year survival rate in the ZTO group were significantly superior to those in the control group (P<0.05). Experimental study showed that the effect in the treated group was better than that in the control group in tumor growth inhibition with the tumor growth rate as 10.8±4.5%% vs 20.6±12.7%

P<0.05

tumor necrosis degree (P<0.01) and survival time prolonged (14.8±3.4 days vs 11.7±1. 9 days

P<0.05) HAPE-ZTO in treating PHC showed the therapeutic effect similar to that of HAPE-C

but superior to the latter in survival time prolongation and bone marrow inhibition.

Abstract

To evaluate the effect

transplantation hepatic carcinoma model was established in 40 rats. They were randomly divided into the treated group and the control group

20 in each group

and were perfused with 10 mg/kg ZTO and 0.2/2-0.3 ml normal saline respectively to observe the effect of treatment. The effect of treatment in the ZTO group was CR in 1 case and PR in 13 cases

the total effective rate being 43.75%

with AFP negative reversed in 7 cases

titer decreased in 7; while in the control group it was PR in 10 cases

the total effective rate being 31. 25%

AFP negative reversed in 5

titer decreased in 2

and the difference of therapeutic effect between the two groups was insignificant (P>0.05). The post-perfusion thrombotic syndrome occurrence

with the symptoms of fever

abdominal pain

vomiting

etc. in the two groups was similar

but no bone marrow inhibition occurred in the ZTO group

which was different from the control group (P<0. 01

P<0.05). The mean survival time

median survival time

3- and 4-year survival rate in the ZTO group was 13.84 months

10 months

37.5%

18.87%

9.70% and 6.4% respectively

and in the control group

8.03 months

6 months

15.6%

6. 27%

0% and 0% respectively

the mean survival time

P<0.05

tumor necrosis degree (P<0.01) and survival time prolonged (14.8±3.4 days vs 11.7±1. 9 days

P<0.05) HAPE-ZTO in treating PHC showed the therapeutic effect similar to that of HAPE-C

but superior to the latter in survival time prolongation and bone marrow inhibition.

关键词

Zedoary turmeric oilhepatic arterial perfusion embolizationPrimary Hepatocarcinoma

Keywords

Zedoary turmeric oilhepatic arterial perfusion embolizationPrimary Hepatocarcinoma

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