Clinical observation on nasopharyngeal carcinoma treated with combined therapy of radiotherapy and ginseng polysaccharide injection

Fang-yun Xie; Zhi-fan Zeng; Hui-ying Huang; Chong Zhao; Tai-xiang Lu

doi:10.1007/BF02934369

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Clinical observation on nasopharyngeal carcinoma treated with combined therapy of radiotherapy and ginseng polysaccharide injection

Updated：2021-08-27

- Clinical observation on nasopharyngeal carcinoma treated with combined therapy of radiotherapy and ginseng polysaccharide injection
- Chinese Journal of Integrative Medicine Vol. 7, Issue 4, Pages: 273-276(2001)
- Affiliations：
  
  Department of Radiotherapy, Cancer Prevention and Treatment Center of Sun Yat-sen University of Medical Sciences,Guangzhou
- Author bio：
- Funds：
- DOI：10.1007/BF02934369
  CLC：
- Published：2001，
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Xie, Fy., Zeng, Zf., Huang, Hy. et al. Clinical observation on nasopharyngeal carcinoma treated with combined therapy of radiotherapy and ginseng polysaccharide injection., CJIM 7, 273–276 (2001). https://doi.org/10.1007/BF02934369

Fang-yun Xie, Zhi-fan Zeng, Hui-ying Huang, et al. Clinical observation on nasopharyngeal carcinoma treated with combined therapy of radiotherapy and ginseng polysaccharide injection. [J]. Chinese Journal of Integrative Medicine 7(4):273-276(2001)
Xie, Fy., Zeng, Zf., Huang, Hy. et al. Clinical observation on nasopharyngeal carcinoma treated with combined therapy of radiotherapy and ginseng polysaccharide injection., CJIM 7, 273–276 (2001). https://doi.org/10.1007/BF02934369 DOI：

Fang-yun Xie, Zhi-fan Zeng, Hui-ying Huang, et al. Clinical observation on nasopharyngeal carcinoma treated with combined therapy of radiotherapy and ginseng polysaccharide injection. [J]. Chinese Journal of Integrative Medicine 7(4):273-276(2001) DOI： 10.1007/BF02934369.

摘要

To observe the effect of radiotherapy (RT) combined with ginseng polysaccharide (GSP) injection in treating nasopharyngeal carcinoma (NPC) and its influence on immune function. One hundred and thirty-one patients of NPC were randomly divided into two groups

the RTGSP group (n=64) treated with RT and GSP

and the control group (n=67) treated with conventional radiotherapy

to observe the local cancer remission rate

1-year total survival rate

no tumor survival rate and no remote metastasis survival rate. Moreover

the changes of T-lymphocyte subsets

natural killer cell (NK) activity and lymphokine-activated killer cell (LAK) activity before and after treatment were determined. Clinical examination conducted 3 months after treatment showed that the complete remission rate in the RT-GSP group was 96.6%

and in the control group 93.3%

the complete remission rate of cervical lymph node metastasis in the two groups was 85. 7% and 78. 0%

the NPC remission rate shown by CT 60.3% and 51.7%

respectively. Re-examination carried out 1 year after treatment showed that the total survival rate in the two groups was 100% and 96. 5%

tumor free survival rate 84.4% and 74.6%

and no remote metastasis survival rate 93. 8% and 88.1% respectively. The activity of NK cell and LAK cell as well as T3

T4 value in peripheral blood increased significantly in the RT-GSP group (allP<0.05) after treatment

while with the control group

no significant influence on NK and LAK activities were shown but significant lowering of T3

T4 was

P<0.05. No toxic-adverse reaction of GSP was found. GSP has certain immune function improving effect in NPC patients during RT

and it could also eliminate the occurred adverse reaction to RT and improve the general condition of patients.

Abstract

the RTGSP group (n=64) treated with RT and GSP

and the control group (n=67) treated with conventional radiotherapy

to observe the local cancer remission rate

1-year total survival rate

no tumor survival rate and no remote metastasis survival rate. Moreover

the changes of T-lymphocyte subsets

and in the control group 93.3%

the complete remission rate of cervical lymph node metastasis in the two groups was 85. 7% and 78. 0%

the NPC remission rate shown by CT 60.3% and 51.7%

respectively. Re-examination carried out 1 year after treatment showed that the total survival rate in the two groups was 100% and 96. 5%

tumor free survival rate 84.4% and 74.6%

and no remote metastasis survival rate 93. 8% and 88.1% respectively. The activity of NK cell and LAK cell as well as T3

T4 value in peripheral blood increased significantly in the RT-GSP group (allP<0.05) after treatment

while with the control group

no significant influence on NK and LAK activities were shown but significant lowering of T3

T4 was

P<0.05. No toxic-adverse reaction of GSP was found. GSP has certain immune function improving effect in NPC patients during RT

and it could also eliminate the occurred adverse reaction to RT and improve the general condition of patients.

关键词

nasopharyngeal cancerradiotherapyginseng polysaccharide injection

Keywords

nasopharyngeal cancerradiotherapyginseng polysaccharide injection

references

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Cao GW, Yang WG, Du P, et al. Clinical observation on polysaccharide of wolfberry fruit combining with LAK/IL-2 therapy in treating 75 cases of advanced tumor. Chin J Oncology 1994; 16(6): 428–431.

Cao GW, Du P. Effect of polysaccharides of astragalus, acanthopanax and wolfberry fruit in regulating anti-tumor activity of LAK cell in vivo. J Second Military Medical University 1993; 13(1): 10.

Zhang EP, Zeng XF, Cai GL, et al. A new suggestion on nasopharyngeal carcinoma staging (II) — results of 5-year follow-up study on 1 422 cases. Cancer 1992; 11(4): 295.

Annew ML, Poon TF, William FOO. Retrospective analysis of 5037 patients with nasopharyngeal carcinoma treated during 1976–1985: Overall survival and patterns of failure. Int J Radiation Oncology Biol Phys 1992; 23: 261.

Kwon WH, Teo PML, Chow LTC, et al. Nasopharyngeal carcinoma with metastatic disease to mediastinal and Hilar lymphnodes: An indication for more aggressive treatment. Clin Oncol 1996;8(1): 65.

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