To observe the leucocyte increasing effect of Shuanghuang Shengbai Granule (SHSBG) in tumor patients treated by chemotherapy and the bone marrow microenvironment protecting effect in mice. Patients of non-small-cell pulmonary

mammary

gastric or intestinal cancer

who were ready for receiving re-treatment of chemotherapy

were enrolled and divided into 4 groups randomly. The 28 cases in SHSBG group A received chemotherapy combined with SHSBG; the 27 in the SHSBG group B received chemotherapy alone at first

and SHSBG was added when their peripheral white blood cell (WBC) count lowered to <4×109/L; the 33 in control group A and 24 in control group B were treated by the method similar to that applied to SHSBG group A and B respectively but with Rubidate instead of SHSBG. Experimental study of electron microscopic observation on bone marrow ultrastructure in mice was also conducted. The total leukocyte increasing effective rate occurred in SHSBG group A and B was 75.00% and 88.89%

while in control group A and B

54.55% and 58.33% respectively

and the difference between the SHSBG groups and the control groups was significant (P<0. 01). Experimental study showed that SHSBG has good bone marrow hematopoietic microenvironment protecting and improving effect in mice. SHSBG has obvious protecting and treating effect on chemotherapy induced bone marrow suppression in tumor patients.