Effect of cistanche desertica polysaccharides on learning and memory functions and infrastructure of cerebral neurons in experimental aging mice

Yun Sun; Yang-mei Deng; De-jun Wang; Chun-feng Shen; Xiao-mei Liu; Hong-quan Zhang

doi:10.1007/BF02934374

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Effect of cistanche desertica polysaccharides on learning and memory functions and infrastructure of cerebral neurons in experimental aging mice

Updated：2021-08-27

- Effect of cistanche desertica polysaccharides on learning and memory functions and infrastructure of cerebral neurons in experimental aging mice
- Chinese Journal of Integrative Medicine Vol. 7, Issue 4, Pages: 288-292(2001)
- Affiliations：
  
  Medical and Pharmacological Institute of Yangzhou University,Jiangsu
- Author bio：
- Funds：
- DOI：10.1007/BF02934374
  CLC：
- Published：2001，
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Sun, Y., Deng, Ym., Wang, Dj. et al. Effect of cistanche desertica polysaccharides on learning and memory functions and infrastructure of cerebral neurons in experimental aging mice., CJIM 7, 288–292 (2001). https://doi.org/10.1007/BF02934374

Yun Sun, Yang-mei Deng, De-jun Wang, et al. Effect of cistanche desertica polysaccharides on learning and memory functions and infrastructure of cerebral neurons in experimental aging mice. [J]. Chinese Journal of Integrative Medicine 7(4):288-292(2001)
Sun, Y., Deng, Ym., Wang, Dj. et al. Effect of cistanche desertica polysaccharides on learning and memory functions and infrastructure of cerebral neurons in experimental aging mice., CJIM 7, 288–292 (2001). https://doi.org/10.1007/BF02934374 DOI：

Yun Sun, Yang-mei Deng, De-jun Wang, et al. Effect of cistanche desertica polysaccharides on learning and memory functions and infrastructure of cerebral neurons in experimental aging mice. [J]. Chinese Journal of Integrative Medicine 7(4):288-292(2001) DOI： 10.1007/BF02934374.

摘要

To observe the effects of Cistanche desertica polysaccharides (CDP) on the learning and memory functions and cerebral ultrastructure in experimental aging mice. CDP was administrated intragastrically 50 or 100 mg/kg per day for 64 successive days to experimental aging model mice induced by D-galactose

then the learning and memory functions of mice were estimated by step-down test and Y-maze test; organelles of brain tissue and cerebral ultrastructure were observed by transmission electron microscope and physical strength was determined by swimming test. CDP could obviously enhance the learning and memory functions (P<0.01) and prolong the swimming time (P<0.05)

decrease the number of lipofuscin and slow down the degeneration of mitochondria in neurons(P<0.05)

and improve the degeneration of cerebral ultra-structure in aging mice. CDP could improve the impaired physiological function and alleviate cerebral morphological change in experimental aging mice.

Abstract

decrease the number of lipofuscin and slow down the degeneration of mitochondria in neurons(P<0.05)

and improve the degeneration of cerebral ultra-structure in aging mice. CDP could improve the impaired physiological function and alleviate cerebral morphological change in experimental aging mice.

关键词

aginglearning and memory functionsCistanche desertica polysaccharidesultra-structureD-galactose

Keywords

aginglearning and memory functionsCistanche desertica polysaccharidesultra-structureD-galactose

references

Sun Y, Lin AP, Zhang HQ. Research of Xinjiang Cistanche desertica on anti-oxidation damage induced by free radicals. China J Chinese Meteria Medica 1994; 19 (7): 433.

Sun Y, Wang DJ, Shen SQ, et al. Observation of Xinjiang Cistanche desertica on hepatocyte and cerebral cortex of aging mice by transmission electron microscope. Traditional Chinese Drug Research 1997; 8(1): 30.

Gong GQ, Xu FB. Study of Aging Model in Mice. J China Pharmaceutical University 1991; 22(2): 101.

Li YK. Experimental methodology of Chinese herbal in Pharmacology. Shanghai: Science and Technology Publishing House 1991: 172.

Zeng ZH, Zhang ZY. Oxidation damage of mitochondrial DNA and aging by free radical. Progr Biochem and Biophys 1995; 22(5): 430.

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