Study of the mechanism of essential garlic oil inhibiting lnterleukin-1 α-induced monocyte adhesion to endothelial cells

Lu-lu Ge; Wei Zhang; Yun Dai; Yan Zang; Chun-jie Huang

doi:10.1007/BF02934376

Your Location：

Home >

Browse articles >

Study of the mechanism of essential garlic oil inhibiting lnterleukin-1 α-induced monocyte adhesion to endothelial cells

Updated：2021-08-27

- Study of the mechanism of essential garlic oil inhibiting lnterleukin-1 α-induced monocyte adhesion to endothelial cells
- Chinese Journal of Integrative Medicine Vol. 7, Issue 4, Pages: 293-296(2001)
- Affiliations：
  
  The First Military Medical University,Guangzhou
- Author bio：
- Funds：
- DOI：10.1007/BF02934376
  CLC：
- Published：2001，
Scan for full text
Ge, Ll., Zhang, W., Dai, Y. et al. Study of the mechanism of essential garlic oil inhibiting lnterleukin-1 α-induced monocyte adhesion to endothelial cells., CJIM 7, 293–296 (2001). https://doi.org/10.1007/BF02934376

Lu-lu Ge, Wei Zhang, Yun Dai, et al. Study of the mechanism of essential garlic oil inhibiting lnterleukin-1 α-induced monocyte adhesion to endothelial cells. [J]. Chinese Journal of Integrative Medicine 7(4):293-296(2001)
Ge, Ll., Zhang, W., Dai, Y. et al. Study of the mechanism of essential garlic oil inhibiting lnterleukin-1 α-induced monocyte adhesion to endothelial cells., CJIM 7, 293–296 (2001). https://doi.org/10.1007/BF02934376 DOI：

Lu-lu Ge, Wei Zhang, Yun Dai, et al. Study of the mechanism of essential garlic oil inhibiting lnterleukin-1 α-induced monocyte adhesion to endothelial cells. [J]. Chinese Journal of Integrative Medicine 7(4):293-296(2001) DOI： 10.1007/BF02934376.

摘要

To observe the effects of essential garlic oil (EGO) on vascular cell adhesive molecule-1 (VCAM-1) expression of endothelial cells and monocyte-endothelial cell adhesion rate induced by interleukin-lα(IL-lα). Human umbilical vein endothelial cells (HUVEC) were isolated by trypsin digestion method and co-cultured with IL-1α or EGO + IL-lα in the absence or presence of U937 monocyte. Monocyte-endothelial cell adhesion rate was examined with reverted microscope. VCAM-1 expression of endothelial cells was measured by ACAS 570 confocal microscope

and the data were presented as mean fluorescent intensity. EGO significantly inhibited IL-lα-induced endothelial expression of VCAM-1

and thus markedly decreased monocyte-endothelial cell adhesion rate. EGO has the effect on antagonizing adhesion of monocyte and vascular endothelial cell

which might be due to its inhibition on adhesive molecular expression on the surface of endothelial cells.

Abstract

and the data were presented as mean fluorescent intensity. EGO significantly inhibited IL-lα-induced endothelial expression of VCAM-1

and thus markedly decreased monocyte-endothelial cell adhesion rate. EGO has the effect on antagonizing adhesion of monocyte and vascular endothelial cell

which might be due to its inhibition on adhesive molecular expression on the surface of endothelial cells.

关键词

essential garlic oilendothelial cellsmonocytesvascular cell adhesive molecule-1interleukin-lα

Keywords

essential garlic oilendothelial cellsmonocytesvascular cell adhesive molecule-1interleukin-lα

references

Cybulsky MI, Fries JW, Williams AJ, et al. Gene structure, chromosal location, and basis for alterative mRNA splicing of the human VCAM -1 gene. Pore Natl Acad Sci USA 1991; 88: 7859–7861.

O’Brien KD, Allen MD, McDonald TO, et al. Vascular cell adhesion molecule-1 is expressed in human coronary atherosclerotic plaques: implications for the mode of progression of advanced coronary atherosclerosis. J Clin Invest 1993; 92(2) : 538–539.

Takahashi M, Kitagawa S, Masuyama JI, et al. Human monocyte-endothelial cell interaction induces synthesis of granulocyte-macrophage colony-stimulating factor. Circulation 1996; 93: 1185–1193.

Yan M, Gong XQ, Zhang YF, et al. Regulation of adhesion molecule expression in leukocytes and endothelial cells. Chin J Pathophysiol 1993; 9(2): 272–275.

Ross R. The pathogenesis of atherosclerosis: A perspective for the 1990s. Nature 1993; 362(29) : 801–809.

Tsao PS, Buitrago R, Chan JR, et al. Fluid flow inhibits endothelial adhesiveness: Nitric oxide and transcriptional regulation of VCAM-1. Circulation 1996; 94(7) : 1682–1689.

De Caterina R, Tanaka H, Nakagawa T, et al. The direct effect of ignitable cyclosporine and its vehicle, cremophor, on endothelial vascular cell adhesion molecule-1 expression. Transplantation 1995; 60(3): 270–275.

Glaser CT, Watson CA, Pardi R, et al. Effect of 17 beta extradiol on cytokine-induced endothelial vascular cell adhesion molecule expression. J Clin Invest 1996; 98(1): 36–42.

Devaraj S, Li D, Jialal I, et al. The effect of alpha tocopherol supplementation on monocyte function. J Clin Invest 1996; 98(3): 756–763.

De Caterina R, Libby P. Control of endothelial leukocyte adhesion molecules by fatty acides. Lipids 1996; 31: S57–63.

Jain AK, Vargas R, Gotzkowsky S. Can garlic reduce levels of serum lipids? A controlled clinical study. A J Medicine 1993; 94: 632–635.

Zhang YQ, Chen Y, Gong WG, et al. Experimental study of atherosclerotic prevention by essential garlic oil. J of Chinese Traditional Patent Medicine Research 1984; 6(1): 23–26.

FULL TEXT LINK

More>

Views

438

Downloads

CSCD

Alert me when the article has been cited

Submit

Tools

Publicity Resources

Effect of Reduqing ( ) on endotoxin-lnduced production of tissue factor and cytokines in human whole blood) on endotoxin-lnduced production of tissue factor and cytokines in human whole blood

Xuebijing Injection (血必净注射液) increases early survival rate by alleviating pulmonary vasopermeability in rats subjected to severe burns

Related Author

No data

Related Institution

Searle-Monsanto Co.

Institution of Integration of Traditional Chinese and Western Medicine, Tongji Medical University

Medical School of Chinese PLA, Chinese PLA General Hospital

Chinese People’s Armed Police Force Academy

Research Department, the Tianjin Chase Sun Pharmaceutical Co., Ltd.

Address：1 Caochang, xiyuan, Beijing, People's Republic of China Postal code：100091
Tel：010-62886827, 62877592 Fax：010-62874291
Technical support is provided by Beijing Founder electronics co., LTD 京ICP备05067934号-1 京公网安备11010802024621
It is recommended to read the content of this site in Chrome&IE9+. Please switch to extreme mode in browser 360.
Cookies We use cookies to help provide and enhance our service and tailor content. By continuing, you agree to the use of cookies.

⁰