Effect of dingxin recipe on intracellular free calcium, membrane potential and mitochondria membrane potential in normal and hypoxia myocytes of rat

Yu-hua Jia; Xue-gang Sun; Xiao-shan Zhao

doi:10.1007/BF02934378

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Effect of dingxin recipe on intracellular free calcium, membrane potential and mitochondria membrane potential in normal and hypoxia myocytes of rat

Updated：2021-08-27

- Effect of dingxin recipe on intracellular free calcium, membrane potential and mitochondria membrane potential in normal and hypoxia myocytes of rat
- Chinese Journal of Integrative Medicine Vol. 7, Issue 4, Pages: 299(2001)
- Affiliations：
  
  Faculty of TCM, The First Military Medical University,Guangzhou
- Author bio：
- Funds：
- DOI：10.1007/BF02934378
  CLC：
- Published：2001，
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Jia, Yh., Sun, Xg. & Zhao, Xs. Effect of dingxin recipe on intracellular free calcium, membrane potential and mitochondria membrane potential in normal and hypoxia myocytes of rat., CJIM 7, 299 (2001). https://doi.org/10.1007/BF02934378

Yu-hua Jia, Xue-gang Sun, Xiao-shan Zhao. Effect of dingxin recipe on intracellular free calcium, membrane potential and mitochondria membrane potential in normal and hypoxia myocytes of rat. [J]. Chinese Journal of Integrative Medicine 7(4):299(2001)
Jia, Yh., Sun, Xg. & Zhao, Xs. Effect of dingxin recipe on intracellular free calcium, membrane potential and mitochondria membrane potential in normal and hypoxia myocytes of rat., CJIM 7, 299 (2001). https://doi.org/10.1007/BF02934378 DOI：

Yu-hua Jia, Xue-gang Sun, Xiao-shan Zhao. Effect of dingxin recipe on intracellular free calcium, membrane potential and mitochondria membrane potential in normal and hypoxia myocytes of rat. [J]. Chinese Journal of Integrative Medicine 7(4):299(2001) DOI： 10.1007/BF02934378.

摘要

To elucidate the molecular mechanism on anti-arrhythmic function of Dingxin Recipe (DXR). Cardiac myocytes isolated by trypsin method were cultured and labeled with various fluorescence stains. DXR contained serum induced changes of cellular calcium concentration [Ca2+]i

cell membrane potential (MP) and mitochondria membrane potential (MMP) were determined with laser confocal microscopy. Hypoxia caused increase of [Ca2+]i and MMP

and decrease of MP

while DXR contained serum lowered the [Ca2+]i in normal or hypoxic myocytes

improved hypoxia induced MP reduction and maintain MMP at baseline level under hypoxia circumstances. Through inhibiting the hypoxia caused [Ca2+]i and MMP elevation and MP lowering

DXR displays its action in protecting myocardial cells to prevent and treat arrhythmia.

Abstract

cell membrane potential (MP) and mitochondria membrane potential (MMP) were determined with laser confocal microscopy. Hypoxia caused increase of [Ca2+]i and MMP

and decrease of MP

while DXR contained serum lowered the [Ca2+]i in normal or hypoxic myocytes

improved hypoxia induced MP reduction and maintain MMP at baseline level under hypoxia circumstances. Through inhibiting the hypoxia caused [Ca2+]i and MMP elevation and MP lowering

DXR displays its action in protecting myocardial cells to prevent and treat arrhythmia.

关键词

Membrane PotentialMitochondrion Membrane PotentialCardiac MyocytesCell Membrane PotentialIntracellular Free Calcium

Keywords

Membrane PotentialMitochondrion Membrane PotentialCardiac MyocytesCell Membrane PotentialIntracellular Free Calcium

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TCM Department, Wuhan General Hospital of Guangzhou Military Area

Cardiovascular Department, Nanhui District Central Hospital

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Internal Medicine Department, Longhua Hospital, Shanghai University of Traditional Chinese Medicine

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