Ren, P., Hu, HJ. & Zhang, R. Observation on efficacy of puerarin in treating diabetic retinopathy., CJIM 8, 24–26 (2002). https://doi.org/10.1007/BF02934613
Ping Ren, Hui-Jun Hu, Rui Zhang. Observation on efficacy of puerarin in treating diabetic retinopathy. [J]. Chinese Journal of Integrative Medicine 8(1):24-26(2002)
Ren, P., Hu, HJ. & Zhang, R. Observation on efficacy of puerarin in treating diabetic retinopathy., CJIM 8, 24–26 (2002). https://doi.org/10.1007/BF02934613DOI:
Ping Ren, Hui-Jun Hu, Rui Zhang. Observation on efficacy of puerarin in treating diabetic retinopathy. [J]. Chinese Journal of Integrative Medicine 8(1):24-26(2002) DOI: 10.1007/BF02934613.
Observation on efficacy of puerarin in treating diabetic retinopathy
摘要
Using the principle of promoting blood circulation to remove stasis to observe central retinal arterial and venous blood flow indexes
and hemorrheology of diabetic retinopathy patients with puerarin. Thirty patients with diabetic retinopathy were randomly divided into the treated group (n= 15) and the control group (n= 15). The treated group was given puerarin 400 mg per day intravenously dripping. The control group was given Mikebao 500 μg intramuscularly
once per day. Both groups were treated for 3 consecutive weeks as one treatment course. Two courses later
hemorrheologic parameters
central retinal arterial and venous blood flow indexes were observed. Comparison before and after treatment showed red blood cell aggregation index
the whole blood viscosity rate
plasma viscosity rate
fibrinogen and erythrocyte sedimentation rate
have all improved obviously (P<0.05
P<0.01). Compared with the control group
there was significant difference (P<0.05
P<0.01). With the treated group before and after treatment
the peak systolic velocity (PSV) of central retinal artery
their end diastolic volume
the acceleration
the central retinal venous reflux velocity have improved respectively. Naked eye visions were also improved
compared with the control group
the difference was significant (P<0.01). Puerarin could reduce blood viscosity
improve microcirculation
and play a positive therapeutic role in diabetic retinopathy.
Abstract
Using the principle of promoting blood circulation to remove stasis to observe central retinal arterial and venous blood flow indexes
and hemorrheology of diabetic retinopathy patients with puerarin. Thirty patients with diabetic retinopathy were randomly divided into the treated group (n= 15) and the control group (n= 15). The treated group was given puerarin 400 mg per day intravenously dripping. The control group was given Mikebao 500 μg intramuscularly
once per day. Both groups were treated for 3 consecutive weeks as one treatment course. Two courses later
hemorrheologic parameters
central retinal arterial and venous blood flow indexes were observed. Comparison before and after treatment showed red blood cell aggregation index
the whole blood viscosity rate
plasma viscosity rate
fibrinogen and erythrocyte sedimentation rate
have all improved obviously (P<0.05
P<0.01). Compared with the control group
there was significant difference (P<0.05
P<0.01). With the treated group before and after treatment
the peak systolic velocity (PSV) of central retinal artery
their end diastolic volume
the acceleration
the central retinal venous reflux velocity have improved respectively. Naked eye visions were also improved
compared with the control group
the difference was significant (P<0.01). Puerarin could reduce blood viscosity
improve microcirculation
and play a positive therapeutic role in diabetic retinopathy.
关键词
Puerarindiabetic retinopathycentral retinal artery and veinhemorrheology
Keywords
Puerarindiabetic retinopathycentral retinal artery and veinhemorrheology
references
Liu Xm. Practical Endocrinology. 2nd edition. Beijing: People’s Military Surgeon Publishing House, 1997: 327–330.
Jiang Xl, Xu L. Effect of puerarin on the improvement of the experimental microcirculation disorder of the mice. Pharmaceutical Acad J 1989;24(4):251–254.
Duan Yj, Wang Sy, Sanron Icchi, et al. The inhibitory effect of five kinds of herbal medicine on the nonenzymic glycosylationof protein. Chin J Diabetes Mellitus 1998;6(4): 227–229.
Induction of adhesion molecule expression in co-culture of human bronchial epithelial cells and neutrophils suppressed by puerarin via down-regulating p38 mitogen-activated protein kinase and nuclear factor κB pathways
In vitro and in vivo effects of puerarin on promotion of osteoblast bone formation
Effect of puerarin on the release of interleukin-8 in co-culture of human bronchial epithelial cells and neutrophils
Puerarin improve insulin resistance of adipocyte through activating Cb1 binding protein path
Effect of Qiming Granule (芪明颗粒) on retinal blood circulation of diabetic retinopathy: A multicenter clinical trial
Related Author
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Related Institution
Deparment of Laboratory Medicine, Wenzhou Medical College
Department of Clinical Laboratory, Chinese People’s Liberation Army General Hospital
Department of Orthopedics, the Second Affiliated Hospital of Medical College of Xi’an Jiaotong University
Department of Orthopedics, the Second Hospital of Tsinghua University
Department of Orthopedics, Shaanxi Provincial People’s Hospital