To evaluate the effect of hematopoietic stem cell transplantation combined with Chinese erbal medicine in treating malignant hematopathy. Allo-bone marrow transplantation (allo-BMT) or allo-peripheral blood stem cell transplantation (allo-PBSCT)

with conditioning regimen of60Co total body irradiation + Cyclophosphamide (TBI+ Cy) or busulfan + cyclophosphamide (Bu + Cy)

was used to treat 4 cases of chronic granulocytic leukemia (CGL

3 of chronic phase and 1 of accelerating phase) and one case of acute non-lymphocytic leukemia (ANLL). And auto-BMT or auto-PBSCT

with conditioning regimen of myleran + cytosino arabinoside + cyclophosphamide (MAC) or MAC+ VP16

was used to treat 7 cases of hematopathy

including 5 cases of ANLL (3 of CR1 and 2 of CR2) and 2 cases of malignant lymphoma (1 of the first occurrence and 1 of relapse). Chinese herbal medicine was given orally to all the 12 patients after transplantation according to TCM Syndrome Differentiation. All patients were successfully engrafted. Within the median follow-up period of 18 (4-70) months

1 patient (8.3%) died a transplantation-related death

3 (25.0%) relapsed and 8 (66.7%) survived free of original disease. CR1 stage of acute leukemia could reduce the relapse rate

when there was no matched bone marow donor; allo-BMT or allo-PBSCT in chronic stage could result in long-term disease-free survival of patients; Chinese herbal medicine administration in patients of malignant hematopathy after transplantation might reduce the complications and plays certain role in promoting recovery of hematopoietic function.