Effects of a herbal formula on biochemical markers of bone turnover in ovariectomlzed rats

Min Xu; Jin-hua Xie; Xiao-hui Zhang; Kett Warren; Prince Richard; Xin-song Feng

doi:10.1007/BF02934618

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Effects of a herbal formula on biochemical markers of bone turnover in ovariectomlzed rats

Updated：2021-08-27

- Effects of a herbal formula on biochemical markers of bone turnover in ovariectomlzed rats
- Chinese Journal of Integrative Medicine Vol. 8, Issue 1, Pages: 44-47(2002)
- Affiliations：
  
  1. Guangzhou University of Traditional Chinese Medicine,Guangzhou,PR China
  2. University of Western Australia,Australia
  3. Institute of Chinese Medicine, Chinese University of Hong Kong, Shatin,Hong Kong
- Author bio：
- Funds：
  
  It is a part of the research of the Chinese-Australian Government Joint Project (1997-C12) supported by Guangdong and Guangzhou Council of Science and Technology and University of Western Australia.
- DOI：10.1007/BF02934618
  CLC：
- Published：2002，
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Xu, M., Xie, Jh., Zhang, Xh. et al. Effects of a herbal formula on biochemical markers of bone turnover in ovariectomlzed rats., CJIM 8, 44–47 (2002). https://doi.org/10.1007/BF02934618

Min Xu, Jin-hua Xie, Xiao-hui Zhang, et al. Effects of a herbal formula on biochemical markers of bone turnover in ovariectomlzed rats. [J]. Chinese Journal of Integrative Medicine 8(1):44-47(2002)
Xu, M., Xie, Jh., Zhang, Xh. et al. Effects of a herbal formula on biochemical markers of bone turnover in ovariectomlzed rats., CJIM 8, 44–47 (2002). https://doi.org/10.1007/BF02934618 DOI：

Min Xu, Jin-hua Xie, Xiao-hui Zhang, et al. Effects of a herbal formula on biochemical markers of bone turnover in ovariectomlzed rats. [J]. Chinese Journal of Integrative Medicine 8(1):44-47(2002) DOI： 10.1007/BF02934618.

摘要

To investigate the effect and mechanism of a Chinese herbal formula MG in ameliorating estrogen deficiency bone loss. 10-month old female rats were randomly divided into three groups: ovariectomized (OVX)

OVX treated with MG decoction (OVX-M) and OVX treated with estrogen injection (OVX-E). The urinary pyridinoline creatinine ratio (Pyd/Cr)

deoxypyridinoline creatinine ratio (Dpd/Cr)

and plasma alkaline phosphatase (ALP) were determined at the baseline

8 and 12 postoperative weeks. Our data showed an average increase of 93% in Pyd/Cr (P<0.001)

180% inDpd/Cr (P <0.005) and 59% in plasma ALP (P<0.001) respectively in the OVX group after ovariectomy. Compared with OVX rats

the increase of the OVX-M group were prevented 39% in Pyd/Cr

102% in Dpd/Cr and 19% in ALP respectively (P<0.05). The herbal formula MG possesses a therapeutic effect on estrogen dependent bone loss by inhibiting the bone turnover as estrogen replacement.

Abstract

OVX treated with MG decoction (OVX-M) and OVX treated with estrogen injection (OVX-E). The urinary pyridinoline creatinine ratio (Pyd/Cr)

deoxypyridinoline creatinine ratio (Dpd/Cr)

and plasma alkaline phosphatase (ALP) were determined at the baseline

8 and 12 postoperative weeks. Our data showed an average increase of 93% in Pyd/Cr (P<0.001)

180% inDpd/Cr (P <0.005) and 59% in plasma ALP (P<0.001) respectively in the OVX group after ovariectomy. Compared with OVX rats

the increase of the OVX-M group were prevented 39% in Pyd/Cr

102% in Dpd/Cr and 19% in ALP respectively (P<0.05). The herbal formula MG possesses a therapeutic effect on estrogen dependent bone loss by inhibiting the bone turnover as estrogen replacement.

关键词

Chinese Herbbone markerovariectomized rat

Keywords

Chinese Herbbone markerovariectomized rat

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