Significance of experiments on the relationship of spleen deficiency syndrome with gastrin and somatostatin changes

Yong-li Yao; Bo Xu; Yu-gang Song; Wan-dai Zhang

doi:10.1007/BF02934620

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Significance of experiments on the relationship of spleen deficiency syndrome with gastrin and somatostatin changes

Updated：2021-08-27

- Significance of experiments on the relationship of spleen deficiency syndrome with gastrin and somatostatin changes
- Chinese Journal of Integrative Medicine Vol. 8, Issue 1, Pages: 51-55(2002)
- Affiliations：
  
  1. Institute of Gastrointestinal Diseases, Nanfang Hospital, the First Military Medical University,Guangzhou
  2. Department of Orthopedics, Nanfang Hospital, the First Military Medical University,China
- Author bio：
- Funds：
  
  Supported by the Military Science Foundation of China, No. 96M060
- DOI：10.1007/BF02934620
  CLC：
- Published：2002，
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Yao, Yl., Xu, B., Song, Yg. et al. Significance of experiments on the relationship of spleen deficiency syndrome with gastrin and somatostatin changes., CJIM 8, 51–55 (2002). https://doi.org/10.1007/BF02934620

Yong-li Yao, Bo Xu, Yu-gang Song, et al. Significance of experiments on the relationship of spleen deficiency syndrome with gastrin and somatostatin changes. [J]. Chinese Journal of Integrative Medicine 8(1):51-55(2002)
Yao, Yl., Xu, B., Song, Yg. et al. Significance of experiments on the relationship of spleen deficiency syndrome with gastrin and somatostatin changes., CJIM 8, 51–55 (2002). https://doi.org/10.1007/BF02934620 DOI：

Yong-li Yao, Bo Xu, Yu-gang Song, et al. Significance of experiments on the relationship of spleen deficiency syndrome with gastrin and somatostatin changes. [J]. Chinese Journal of Integrative Medicine 8(1):51-55(2002) DOI： 10.1007/BF02934620.

摘要

To explore the relationship among gastrin

somatostatin and pathogenesis of spleen deficiency syndrome (SDS). The changes of gastrin and somatostatin in body fluid and tissues were measured by radioimmunoassay. G cells (gastrin cells) and D cells (somatostatin cells) of gastroduodenal mucosa were analyzed with polyclonal antibody to gastrin and somatostatin

immunohistochemical technique and Quantimet 500 image analysis system. Sijunzi decoction (

SJZD) was chosen for counter-confirmation of syndrome. The levels of gastrin in plasma

gastric juice

intestinal juice

gastric antrum

duodenum and hypothalamus of experimental SDS were significantly lowered and somatostatin markedly higher than the control group

which was improved and even better than spontaneous recovery group after prevention and treatment with SJZD (P<0.05). The count of G cells and D cells reduced (P<0.05 )

the area of D cells declined (P<0.05)

but mean grey of G cells elevated (P<0.05) and ratio of the count and area on G/D also increased (P<0.05) in experimental SDS

which was improved and even better than spontaneous recovery group after prevention and treatment with SJZD (P<0.05). The study confirmed that disturbance of relationship between gastrin and somatostatin would lead to gastrointestinal disorder

which was one of important causes for pathogenesis of SDS.

Abstract

To explore the relationship among gastrin

immunohistochemical technique and Quantimet 500 image analysis system. Sijunzi decoction (

SJZD) was chosen for counter-confirmation of syndrome. The levels of gastrin in plasma

gastric juice

intestinal juice

gastric antrum

duodenum and hypothalamus of experimental SDS were significantly lowered and somatostatin markedly higher than the control group

which was improved and even better than spontaneous recovery group after prevention and treatment with SJZD (P<0.05). The count of G cells and D cells reduced (P<0.05 )

the area of D cells declined (P<0.05)

but mean grey of G cells elevated (P<0.05) and ratio of the count and area on G/D also increased (P<0.05) in experimental SDS

which was one of important causes for pathogenesis of SDS.

关键词

gastrinsomatostatinspleen deficiency

Keywords

gastrinsomatostatinspleen deficiency

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