Experimental study of the inhibitory effect of gantai capsule on HBsAg and HBeAg expression

Yan-ling Zhao; Hai-long Yuan; Xiao-he Xiao; Lin Hu; Cheng-shan He

doi:10.1007/BF02934621

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Experimental study of the inhibitory effect of gantai capsule on HBsAg and HBeAg expression

Updated：2021-08-27

- Experimental study of the inhibitory effect of gantai capsule on HBsAg and HBeAg expression
- Chinese Journal of Integrative Medicine Vol. 8, Issue 1, Pages: 56-58(2002)
- Affiliations：
  
  Department of Pharmacy, Hospital of PLA,Beijing,302
- Author bio：
- Funds：
- DOI：10.1007/BF02934621
  CLC：
- Published：2002，
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Zhao, Yl., Yuan, Hl., Xiao, Xh. et al. Experimental study of the inhibitory effect of gantai capsule on HBsAg and HBeAg expression., CJIM 8, 56–58 (2002). https://doi.org/10.1007/BF02934621

Yan-ling Zhao, Hai-long Yuan, Xiao-he Xiao, et al. Experimental study of the inhibitory effect of gantai capsule on HBsAg and HBeAg expression. [J]. Chinese Journal of Integrative Medicine 8(1):56-58(2002)
Zhao, Yl., Yuan, Hl., Xiao, Xh. et al. Experimental study of the inhibitory effect of gantai capsule on HBsAg and HBeAg expression., CJIM 8, 56–58 (2002). https://doi.org/10.1007/BF02934621 DOI：

Yan-ling Zhao, Hai-long Yuan, Xiao-he Xiao, et al. Experimental study of the inhibitory effect of gantai capsule on HBsAg and HBeAg expression. [J]. Chinese Journal of Integrative Medicine 8(1):56-58(2002) DOI： 10.1007/BF02934621.

摘要

To study the inhibitory effect of Gantai capsules (GTC) on replication and expression of HBsAg and HBeAg. The 2.2.15 cell line was chosen as a in vitro cell culture system

and by means of radioimmunoassay

the hepatitis B surface antigen (HBsAg) and hepatitis B e antigen (HBeAg) in cell cultured medium were examined. HBsAg

HBeAg values of 2.2.15 cells treated by GTC (200 µg/ml- 1200 µg/ml) were lower than those of the control. And this inhibitory effect was in a dose-dependent manner under experimental condition

GTC had no cytotoxicity. GTC could inhibit HBV replication and expression.

Abstract

To study the inhibitory effect of Gantai capsules (GTC) on replication and expression of HBsAg and HBeAg. The 2.2.15 cell line was chosen as a in vitro cell culture system

and by means of radioimmunoassay

the hepatitis B surface antigen (HBsAg) and hepatitis B e antigen (HBeAg) in cell cultured medium were examined. HBsAg

HBeAg values of 2.2.15 cells treated by GTC (200 µg/ml- 1200 µg/ml) were lower than those of the control. And this inhibitory effect was in a dose-dependent manner under experimental condition

GTC had no cytotoxicity. GTC could inhibit HBV replication and expression.

关键词

Gantai capsulehepatitis B virusinhibitionradioimmunoassay

Keywords

Gantai capsulehepatitis B virusinhibitionradioimmunoassay

references

Brend E, Korba. In vitro elevation of combination on therapies against hepatitis B virus replication. J Antiviral Res 1995; 29: 49–51.

YANG L, Yao JL, Deng LX. Inhibition of hepatitis B replication and synthesis of antigen by antisense oligode-oxynuleotides in vitro. J Chin Infec Disea 2000; 18(1): 13–15.

Tim Mosmann. Rapid colorimetric assay for cellular growth and survival: Application to proliferation and cytotoxicity assays. J Immunol Methods 1983; 65: 55–63.

Brent E, Korba, Gregory Milman. A cell culture assay for compounds which inhibit hepatitis B virus replication. J Antiviral Res 1993; 27: 217–226.

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Department of Immunology and Microbiology, Beijing University of Chinese Medicine

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