To investigate the effect of New Zhengtian Pill (NZTP) on expression of whole blood platelet membrane adhesion molecules (PMAM) in patients of migraine. Sixty-eight patients were divided into two groups

the 35 patients in the treated group treated by NZTP orally and the 33 patients in the control group treated by Fuguiqin Capsule with a therapeutic course of 30 days for both groups. Changes of PMAM GP II b/III a (CD41) and P-selectin (CD62P) were observed by flow-cytometry and compared with those in healthy persons. The markedly effective rate and total effective rate in the treated group was higher than those in the control group respectively (P<0.05 andP<0.01). The PMAM expression was also higher in patients

both at onset stage and intermittent stage

than in healthy persons (P<0.01)

NZTP treatment could reduce their increased expression significantly (P<0.01). NZTP could reduce the PMAM expression and inhibit the activation of platelet.