Clinical and experimental study on Fuzheng Baozhen Decoction ( ) in enhancing effect of radio- and chemotherapy for malignant tumors) in enhancing effect of radio- and chemotherapy for malignant tumors

Li Jing; Li Xinqun; Li Jiabang; Liang Qinghua; Xiang Yueqian; Yuan Jun; Tang Lili

doi:10.1007/BF02934650

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Clinical and experimental study on Fuzheng Baozhen Decoction ( ) in enhancing effect of radio- and chemotherapy for malignant tumors) in enhancing effect of radio- and chemotherapy for malignant tumors

Updated：2021-08-27

- Clinical and experimental study on Fuzheng Baozhen Decoction ( ) in enhancing effect of radio- and chemotherapy for malignant tumors) in enhancing effect of radio- and chemotherapy for malignant tumors
- Chinese Journal of Integrative Medicine Vol. 5, Issue 2, Pages: 95-100(1999)
- Affiliations：
  
  1. Institute of Integrated Traditional Chinese and Western Medicine, Hunan Medical University,Changsha
  2. Xiangya Hospital, Hunan Medical University,Changsha
- Author bio：
- Funds：
- DOI：10.1007/BF02934650
  CLC：
- Published：1999，
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Jing, L., Xinqun, L., Jiabang, L. et al. Clinical and experimental study on Fuzheng Baozhen Decoction () in enhancing effect of radio- and chemotherapy for malignant tumors) in enhancing effect of radio- and chemotherapy for malignant tumors., CJIM 5, 95–100 (1999). https://doi.org/10.1007/BF02934650

Li Jing, Li Xinqun, Li Jiabang, et al. Clinical and experimental study on Fuzheng Baozhen Decoction ( ) in enhancing effect of radio- and chemotherapy for malignant tumors) in enhancing effect of radio- and chemotherapy for malignant tumors. [J]. Chinese Journal of Integrative Medicine 5(2):95-100(1999)
Jing, L., Xinqun, L., Jiabang, L. et al. Clinical and experimental study on Fuzheng Baozhen Decoction () in enhancing effect of radio- and chemotherapy for malignant tumors) in enhancing effect of radio- and chemotherapy for malignant tumors., CJIM 5, 95–100 (1999). https://doi.org/10.1007/BF02934650 DOI：

Li Jing, Li Xinqun, Li Jiabang, et al. Clinical and experimental study on Fuzheng Baozhen Decoction ( ) in enhancing effect of radio- and chemotherapy for malignant tumors) in enhancing effect of radio- and chemotherapy for malignant tumors. [J]. Chinese Journal of Integrative Medicine 5(2):95-100(1999) DOI： 10.1007/BF02934650.

摘要

Objective: To study on Fuzheng Baozhen Decoction (FZBZD) enhancing effect of radio- and chemotherapy for malignant tumors. Methods: One hundred and Seventeen cases of malignant tumors treated with chemotherapy or/and radiotherapy. Among them 55 cases were treated together with FZBZD (group A)

30 cases together with Zhenqi Fuzheng Granules (group B)

and the other 32 cases treated with radio- and chemotherapy alone (group C). Mechanism of FZBZD enhancing effect of chemotherapy in treating transplanted human lung adenocarcinoma (SPC-A-1) and sarcoma (S180) bearing mice was conducted experimentally. Results: Effective rates (CR+PR) of group A

B and C were 63.6%

43.3% and 37.5% respectively

that of group A being the best (P < 0.05). The survival quality of life was improved the most in group A (P < 0.05). The picture of peripheral blood (WBC

PLT count) of group A after treatment was better than that of the other two groups (P < 0.05). And CD3

CD4

NK activity

interleukin-2 levels were also improved more significantly in group A (P < 0.01) than those in the other two. Animal experiment showed that FZBZD could improve the effect of chemotherapy in inhibiting tumor growth (P < 0.01)

raising cAMP/cGMP ratio (P < 0. 01) by increasing the cAMP level in cancer tissue

and enhancing cells ofG0/G1 phase and reducing cells of S phase. Conclusion: FZBZD inhibited tumor growth and enhanced the effect of radio- and chemotherapy by improving immune and hematopoietic function

cAMP/cGMP ratio and halting tumor cells in G0/G1 phase.

Abstract

30 cases together with Zhenqi Fuzheng Granules (group B)

B and C were 63.6%

43.3% and 37.5% respectively

that of group A being the best (P < 0.05). The survival quality of life was improved the most in group A (P < 0.05). The picture of peripheral blood (WBC

PLT count) of group A after treatment was better than that of the other two groups (P < 0.05). And CD3

CD4

NK activity

raising cAMP/cGMP ratio (P < 0. 01) by increasing the cAMP level in cancer tissue

cAMP/cGMP ratio and halting tumor cells in G0/G1 phase.

关键词

Fuzheng Baozhen Decoctionmalignant tumorchemotherapyradiotherapycells cycle

Keywords

Fuzheng Baozhen Decoctionmalignant tumorchemotherapyradiotherapycells cycle

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Scala S, Budillon A, Zhan Z, et al. Downregulation of mdr-1 expression by 8-C1-cAMP in multidrug resistant MCF-7 human breast cancer cells. J Clin Invest 1995; 96 (2): 1026–1034.

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