Effects of Schisanhenol on respiratory burst in rat neutrophils

Zhang Kejian; Liu Gengtao

doi:10.1007/BF02934666

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Effects of Schisanhenol on respiratory burst in rat neutrophils

Updated：2021-08-27

- Effects of Schisanhenol on respiratory burst in rat neutrophils
- Chinese Journal of Integrative Medicine Vol. 5, Issue 2, Pages: 134-137(1999)
- Affiliations：
  
  1. Beijing Hospital, National Center for Clinical Laboratories,Beijing
  2. Institute of Materia Medica, Chinese Academy of Medical Sciences,Beijing
- Author bio：
- Funds：
  
  Project was supported by the National Science Foundation of China (No. 39170232) and Huo Yingdong Education Foundation
- DOI：10.1007/BF02934666
  CLC：
- Published：1999，
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Kejian, Z., Gengtao, L. Effects of Schisanhenol on respiratory burst in rat neutrophils., CJIM 5, 134–137 (1999). https://doi.org/10.1007/BF02934666

Zhang Kejian, Liu Gengtao. Effects of Schisanhenol on respiratory burst in rat neutrophils. [J]. Chinese Journal of Integrative Medicine 5(2):134-137(1999)
Kejian, Z., Gengtao, L. Effects of Schisanhenol on respiratory burst in rat neutrophils., CJIM 5, 134–137 (1999). https://doi.org/10.1007/BF02934666 DOI：

Zhang Kejian, Liu Gengtao. Effects of Schisanhenol on respiratory burst in rat neutrophils. [J]. Chinese Journal of Integrative Medicine 5(2):134-137(1999) DOI： 10.1007/BF02934666.

摘要

Objective: To explore the effects of Schisanhenol (Sal) on generation of reactive oxygen species (ROS) including superoxide anion

hydrogen peroxide and hydroxyl radical as well as on the activity of superoxide dismutase (SOD) and catalase in respiratory burst of rat neutrophils.Methods: Rat neutrophils were prepared from male Wistar rats. Superoxide anion

hydrogen peroxide

hydroxyl radical

SOD and catalase activity were measured.Results: Sal (1

100 μmol/L) inhibited generation of ROS of rat neutrophils during respiratory burst induced by formyl-methionyleucylphenylalanine (FMLP) and phorbol myristate acetate (PMA) dosedependently

and it enhanced SOD and catalase activities.Conclusion: Sal may inhibit generation of ROS and enhance activity of anti-oxidant enzymes of neutrophils to reduce oxidative injury to tissues.

Abstract

Objective: To explore the effects of Schisanhenol (Sal) on generation of reactive oxygen species (ROS) including superoxide anion

hydrogen peroxide

hydroxyl radical

SOD and catalase activity were measured.Results: Sal (1

100 μmol/L) inhibited generation of ROS of rat neutrophils during respiratory burst induced by formyl-methionyleucylphenylalanine (FMLP) and phorbol myristate acetate (PMA) dosedependently

and it enhanced SOD and catalase activities.Conclusion: Sal may inhibit generation of ROS and enhance activity of anti-oxidant enzymes of neutrophils to reduce oxidative injury to tissues.

关键词

Schisanhenolneutrophilsfree radicalssuperoxide dismutasecatalase

Keywords

Schisanhenolneutrophilsfree radicalssuperoxide dismutasecatalase

references

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