Effect of Shengmaisan ( ) on lipid peroxidation damage in acute myocardial infarction patients) on lipid peroxidation damage in acute myocardial infarction patients

Bao-Jing Lu; Ye-Zhi Rong; Mei-Hua Zhao; Guo-Fang Huang; Xiang-Yang Zhu; Jin-Wen Yang

doi:10.1007/BF02934685

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Effect of Shengmaisan ( ) on lipid peroxidation damage in acute myocardial infarction patients) on lipid peroxidation damage in acute myocardial infarction patients

Updated：2021-08-27

- Effect of Shengmaisan ( ) on lipid peroxidation damage in acute myocardial infarction patients) on lipid peroxidation damage in acute myocardial infarction patients
- Chinese Journal of Integrative Medicine Vol. 2, Issue 4, Pages: 249-251(1996)
- Affiliations：
  
  Department of Cardiology, Xinhua Hospital, Shanghai Second Medical University,Shanghai
- Author bio：
- Funds：
- DOI：10.1007/BF02934685
  CLC：
- Published：1996，
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Lu, BJ., Rong, YZ., Zhao, MH. et al. Effect of Shengmaisan () on lipid peroxidation damage in acute myocardial infarction patients) on lipid peroxidation damage in acute myocardial infarction patients., CJIM 2, 249–251 (1996). https://doi.org/10.1007/BF02934685

Bao-Jing Lu, Ye-Zhi Rong, Mei-Hua Zhao, et al. Effect of Shengmaisan ( ) on lipid peroxidation damage in acute myocardial infarction patients) on lipid peroxidation damage in acute myocardial infarction patients. [J]. Chinese Journal of Integrative Medicine 2(4):249-251(1996)
Lu, BJ., Rong, YZ., Zhao, MH. et al. Effect of Shengmaisan () on lipid peroxidation damage in acute myocardial infarction patients) on lipid peroxidation damage in acute myocardial infarction patients., CJIM 2, 249–251 (1996). https://doi.org/10.1007/BF02934685 DOI：

Bao-Jing Lu, Ye-Zhi Rong, Mei-Hua Zhao, et al. Effect of Shengmaisan ( ) on lipid peroxidation damage in acute myocardial infarction patients) on lipid peroxidation damage in acute myocardial infarction patients. [J]. Chinese Journal of Integrative Medicine 2(4):249-251(1996) DOI： 10.1007/BF02934685.

摘要

The effect of Shengmaisan (SMS) on coronary heart disease (CHD) patients

30 angina pectoris and 68 acute myocardial infarction (AMI) and its peroxidation damage was studied. It was shown that the activities of superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px) in blood decreased and the content of malondialdehyde (MDA) in plasma increased in CHD patients in comparison with the healthy controls (P<0.001). When SMS was orally administered in 38 AMI patients

both SOD and GSH-Px activities were increased and the level of MDA decreased (P<0. 05)

and these changes were even more significant when SMS was further ingested for another two weeks (P<0. 001). AT the same time

it was found that the changes of SOD

GSH-Px and MDA in the control group (30 AMI patients not taking SMS) were not significantly different (P>0. 05). It could be assumed that the pathogenesis of CHD is associated with free radical (FR) triggering a chain reaction of the lipid peroxidation

and that SMS is acting as an effective free radical scavenger

which would ameliorate the lipid peroxidation damage. Thus

SMS could be administered in the prevention and the treatment of CHD.

Abstract

The effect of Shengmaisan (SMS) on coronary heart disease (CHD) patients

both SOD and GSH-Px activities were increased and the level of MDA decreased (P<0. 05)

and these changes were even more significant when SMS was further ingested for another two weeks (P<0. 001). AT the same time

it was found that the changes of SOD

and that SMS is acting as an effective free radical scavenger

which would ameliorate the lipid peroxidation damage. Thus

SMS could be administered in the prevention and the treatment of CHD.

关键词

Shengmaisanacute myocardial infarctionfree radicallipid peroxidation

Keywords

Shengmaisanacute myocardial infarctionfree radicallipid peroxidation

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