Effects of Radix Astragali on left ventricular function and oxygen free radicals in acute myocardial infarction patients and its mechanism of cardiotonic action

Li-Xin Chen; Jia-Zhen Liao; Wei-Qin Guo; Wei-Jie Yu; La-Mei Qin

doi:10.1007/BF02934686

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Effects of Radix Astragali on left ventricular function and oxygen free radicals in acute myocardial infarction patients and its mechanism of cardiotonic action

Updated：2021-08-27

- Effects of Radix Astragali on left ventricular function and oxygen free radicals in acute myocardial infarction patients and its mechanism of cardiotonic action
- Chinese Journal of Integrative Medicine Vol. 2, Issue 4, Pages: 252-254(1996)
- Affiliations：
  
  1. Departent of Emergency,Beijing
  2. Department of Cardiology Dongzhimen Hospital, Beijing University of Traditional Chinese Medicine,Beijing
- Author bio：
- Funds：
- DOI：10.1007/BF02934686
  CLC：
- Published：1996，
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Chen, LX., Liao, JZ., Guo, WQ. et al. Effects of Radix Astragali on left ventricular function and oxygen free radicals in acute myocardial infarction patients and its mechanism of cardiotonic action., CJIM 2, 252–254 (1996). https://doi.org/10.1007/BF02934686

Li-Xin Chen, Jia-Zhen Liao, Wei-Qin Guo, et al. Effects of Radix Astragali on left ventricular function and oxygen free radicals in acute myocardial infarction patients and its mechanism of cardiotonic action. [J]. Chinese Journal of Integrative Medicine 2(4):252-254(1996)
Chen, LX., Liao, JZ., Guo, WQ. et al. Effects of Radix Astragali on left ventricular function and oxygen free radicals in acute myocardial infarction patients and its mechanism of cardiotonic action., CJIM 2, 252–254 (1996). https://doi.org/10.1007/BF02934686 DOI：

Li-Xin Chen, Jia-Zhen Liao, Wei-Qin Guo, et al. Effects of Radix Astragali on left ventricular function and oxygen free radicals in acute myocardial infarction patients and its mechanism of cardiotonic action. [J]. Chinese Journal of Integrative Medicine 2(4):252-254(1996) DOI： 10.1007/BF02934686.

摘要

Dynamic observations for 4 weeks were made on left ventricular function and oxygen free radicals (OFR) in 43 patients who suffered the first attack of acute myocardial infarction and was hospitalized in Coronary Care Unit within 36 hours. The results showed that Radix Astragali (RA) could strenthen the left ventricular function and had an effect of scavenging OFR. After administration of RA

the ratio of pre-ejection period/left ventricular ejection time (PEP/LVET) was decreased

the superoxide dismutase (SOD) activities of erythrocytes were increased

and the lipid peroxidation (LPO) concentration of plasma was reduced. There was a significant difference between the RA group and the control group in the parameters mentioned above. The study demonstrated that the PEP/LVET ratio was closely correlated with SOD and LPO. It suggested that the scavenging effect of RA on OFR was one of its mechanisms of cardiotonic action.

Abstract

the ratio of pre-ejection period/left ventricular ejection time (PEP/LVET) was decreased

the superoxide dismutase (SOD) activities of erythrocytes were increased

关键词

Radix Astragaliacute myocardial infarctionpre-ejection period/left ventricular ejection timesuperoxide dismutaselipid peroxidation

Keywords

Radix Astragaliacute myocardial infarctionpre-ejection period/left ventricular ejection timesuperoxide dismutaselipid peroxidation

references

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McMurray J, Mclay J, Chopra M, et al. Evidence for enhanced free radical activity in chronic congestive heart failure secondary to coronary artery disease. Am J Cardiol 1990; 65 (5): 1261

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