Clinical study on Zhengan Xifeng ( ) Decoction in preventing and treating hypertensive nephropathy) Decoction in preventing and treating hypertensive nephropathy

Bo-Ke Zhang; Zheng-Hui Zhao; Han-Min Wang; Jun Zhu

doi:10.1007/BF02934693

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Clinical study on Zhengan Xifeng ( ) Decoction in preventing and treating hypertensive nephropathy) Decoction in preventing and treating hypertensive nephropathy

Updated：2021-08-27

- Clinical study on Zhengan Xifeng ( ) Decoction in preventing and treating hypertensive nephropathy) Decoction in preventing and treating hypertensive nephropathy
- Chinese Journal of Integrative Medicine Vol. 2, Issue 4, Pages: 270-273(1996)
- Affiliations：
  
  Department of Nephrology, Xijing Hosptial, The 4th Military Medical University,Xi’an
- Author bio：
- Funds：
- DOI：10.1007/BF02934693
  CLC：
- Published：1996，
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Zhang, BK., Zhao, ZH., Wang, HM. et al. Clinical study on Zhengan Xifeng () Decoction in preventing and treating hypertensive nephropathy) Decoction in preventing and treating hypertensive nephropathy., CJIM 2, 270 (1996). https://doi.org/10.1007/BF02934693

Bo-Ke Zhang, Zheng-Hui Zhao, Han-Min Wang, et al. Clinical study on Zhengan Xifeng ( ) Decoction in preventing and treating hypertensive nephropathy) Decoction in preventing and treating hypertensive nephropathy. [J]. Chinese Journal of Integrative Medicine 2(4):270-273(1996)
Zhang, BK., Zhao, ZH., Wang, HM. et al. Clinical study on Zhengan Xifeng () Decoction in preventing and treating hypertensive nephropathy) Decoction in preventing and treating hypertensive nephropathy., CJIM 2, 270 (1996). https://doi.org/10.1007/BF02934693 DOI：

Bo-Ke Zhang, Zheng-Hui Zhao, Han-Min Wang, et al. Clinical study on Zhengan Xifeng ( ) Decoction in preventing and treating hypertensive nephropathy) Decoction in preventing and treating hypertensive nephropathy. [J]. Chinese Journal of Integrative Medicine 2(4):270-273(1996) DOI： 10.1007/BF02934693.

摘要

Seventeen cases of hypertensive nephropathy with azotemia (test group) treated with Zhengan Xifeng Decoction (ZGXFD) and a routine regimen of Western Medicine were observed. The result was compared with that of 15 cases treated with routine regimen alone (control.group). After 3 months of treatment

the blood pressure

sodium excretion

blood urea nitrogen and creatinine were all reduced

while creatinine clearance rate (CCr) and residual renal function index (RRFI) were improved significantly in both groups. Compared with the control group

the treatment on the test group showed a more prominent effect on lowering of diastolic blood pressure

elevating the hemoglobin

reducing the blood level of triglyceride and creatinine as well as improving on CCr and RRFI

suggesting the deterioration of residual renal function could be restrained by ZGXFD

through improving the disorder of lipid metabolism

osmolality gradient and creatinine kinetics.

Abstract

the blood pressure

sodium excretion

blood urea nitrogen and creatinine were all reduced

while creatinine clearance rate (CCr) and residual renal function index (RRFI) were improved significantly in both groups. Compared with the control group

the treatment on the test group showed a more prominent effect on lowering of diastolic blood pressure

elevating the hemoglobin

reducing the blood level of triglyceride and creatinine as well as improving on CCr and RRFI

suggesting the deterioration of residual renal function could be restrained by ZGXFD

through improving the disorder of lipid metabolism

osmolality gradient and creatinine kinetics.

关键词

hypertensionarteriolar nephrosclerosisresidual renal functionZhengan Xifeng Decoction

Keywords

hypertensionarteriolar nephrosclerosisresidual renal functionZhengan Xifeng Decoction

references

Luck RC, Strom TB. Chronic renal failure. In: Stein JH, eds. Internal medicine, 3rd ed. Boston: Little, Brown and Company, 1990:802.

Dunn MJ, Smith MC. The patients with hypertension. In: Schrier RW, eds. Manual of nephrology: diagnosis and therapy, 3rd ed. Boston: Little, Brown and Company, 1990: 226–258.

Raine AEG. Hypertension and the kidney. Br Med Bull 1994; 50:332.

Lindeman RD, Tobin JD, Shock NW. Hypertension and the kidney. Nephron 1987; 47:S62.

Lacombe C, Dasilva JL, Bruneval P, et al. Peritubular cells are the site of erythropoietin synthesis in the murine hypoxic kidney. J Clin Invest 1988; 81:620.

Anderson S, Meyer TW, Remike HG, et al. Control of glomerular hypertension limits glomerular injury in rats with reduced renal mass. J Clin Invest 1985; 76:612.

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