Objective: The effect and side-effect of epidural injection with lappaconitine compound for post-operative analgesia was observed.Methods: One hundred and twenty patients were randomly divided into 4 groups. Lappaconitine compound (LB) consisted of 12 mg of lappaconitine and 22.5 mg of bupivacaine

was used for the observed group

and lappaconitine 12 mg

bupivacaine 22.5 mg and morphine 2 mg for the control group respectively

All were given by epidural injection with single blind method during post-operative pain of incision operation.Results: It was showed that the initiating of analgesia was earlier in LB and bupivacaine group than that in group B and D

and the efficacy was morphine group > LB > bupivacaine > lappaconitine. There was significant difference between group A and B in the above two parameters

P < 0.01 andP < 0.05. The analgesia maintenance time of a single injection was morphine >LB> lappaconitine> bupivacaine

that of group D was significantly longer than that of group A (P < 0.01).Conclusions: It indicated that the epidural injection with LB was more rapid and potent than that with lappaconitine alone in post-operative analgesia. Besides

it had no side-effect and safer than morphine.