Clinical study of Jinmaitong composita ( )on diabetic peripheral neuropathy)on diabetic peripheral neuropathy

Xiao-Chun Liang; Li-Ying Cui; Sai-Shan Guo; Ke-Jian Zhang; Wei-Xin Hao; Li Jia; Hong Zhang; Ren-Yu Sun; Ben-Hong Li; Hong Du

doi:10.1007/BF02935013

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Clinical study of Jinmaitong composita ( )on diabetic peripheral neuropathy)on diabetic peripheral neuropathy

Updated：2021-08-27

- Clinical study of Jinmaitong composita ( )on diabetic peripheral neuropathy)on diabetic peripheral neuropathy
- Chinese Journal of Integrative Medicine Vol. 7, Issue 2, Pages: 103-106(2001)
- Affiliations：
  
  1. Peking Union Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences,Beijing
  2. Peking Union Medical College, Basic Research Institute of Chinese Academy of Medical Sciences,Beijing
- Author bio：
- Funds：
- DOI：10.1007/BF02935013
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- Published：2001，
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Liang, XC., Cui, LY., Guo, SS. et al. Clinical study of Jinmaitong composita ()on diabetic peripheral neuropathy)on diabetic peripheral neuropathy., CJIM 7, 103–106 (2001). https://doi.org/10.1007/BF02935013

Xiao-Chun Liang, Li-Ying Cui, Sai-Shan Guo, et al. Clinical study of Jinmaitong composita ( )on diabetic peripheral neuropathy)on diabetic peripheral neuropathy. [J]. Chinese Journal of Integrative Medicine 7(2):103-106(2001)
Liang, XC., Cui, LY., Guo, SS. et al. Clinical study of Jinmaitong composita ()on diabetic peripheral neuropathy)on diabetic peripheral neuropathy., CJIM 7, 103–106 (2001). https://doi.org/10.1007/BF02935013 DOI：

Xiao-Chun Liang, Li-Ying Cui, Sai-Shan Guo, et al. Clinical study of Jinmaitong composita ( )on diabetic peripheral neuropathy)on diabetic peripheral neuropathy. [J]. Chinese Journal of Integrative Medicine 7(2):103-106(2001) DOI： 10.1007/BF02935013.

摘要

Objective: To verify the effect of Jinmaitong composita (JMTC) on red blood cell aldose reductase activity (RBC-AR)

red blood cell sorbitol (RBC-S) and nerve conductive velocity in diabetic peripheral neuropathy (DN) patients. Methods: Sixty-six patients with DN were randomly divided into two groups

33 patients in the treated group treated with JMTC and 33 patients in the control group treated with Jingui Shenqi capsule (JGSQ). RBC-AR

RBC-S and nerve transmission speed were observed before and after three months treatment.Results: Level of RBC-AR

RBC-S apparently decreased and nerve conductive velocity increased (P <0.05

P<0.01) after JMTC treatment.Conclusion: JMTC can improve the nerve conductive velocity significantly with a lowering of RBC-AR and RBC-S and has a good result in treating diabetic peripheral neuropathy.

Abstract

Objective: To verify the effect of Jinmaitong composita (JMTC) on red blood cell aldose reductase activity (RBC-AR)

red blood cell sorbitol (RBC-S) and nerve conductive velocity in diabetic peripheral neuropathy (DN) patients. Methods: Sixty-six patients with DN were randomly divided into two groups

33 patients in the treated group treated with JMTC and 33 patients in the control group treated with Jingui Shenqi capsule (JGSQ). RBC-AR

RBC-S and nerve transmission speed were observed before and after three months treatment.Results: Level of RBC-AR

RBC-S apparently decreased and nerve conductive velocity increased (P <0.05

关键词

Jinmaitong composita (JMTC)diabetic peripheral neuropathynerve conductive velocityaldose reductase activitysorbitol

Keywords

Jinmaitong composita (JMTC)diabetic peripheral neuropathynerve conductive velocityaldose reductase activitysorbitol

references

Song Hp, Li J, Han Xy, et al. Red blood cell aldose reductase activity and cell damage of NIDDM patients. Chin J Endocrinol Metab 1992;8(2): 72–74.

Zhou Yp, Zhang Jq. Measurement of aldose reductase by fluorescence intensity and its utilization on measuring lens AR of diabetic rats. Chin J Endocrinol Metab 1989;5(3):159–161.

Greene Da, Lattimer Sa. Altered sorbitol and myo-inositol metabolism as the basis for defective protein kinase C and Na+-K+-ATPase regulation in diabetic neuropathy. Ann NY Acad Sci 1986; 488:344–340.

Hotta N, Kakuta H, Fukasawa M, et al. Effects of a fructose-rich diet and the aldose reductase inhibitor, ONO-2235, on the development of diabetic neuropathy in streptozotocintreated rats. Diabetologia 1985; 28:176–180.

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Related Institution

Department of Traditional Chinese Medicine, Translational Medicine Center, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences

Xiyuan Hospital, China Academy of Chinese Medical Sciences

Beijing Union Hospital, PUMC, Academy of Chinese Medical Sciences

Department of Endocrinology, Changhai Hospital, Second Military Medical University

Department of Pathology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences, School of Basic Medicine, Peking Union Medical College

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