Study on the effect of Chinese herbal medicine in regulating peritoneal lymphatic stomata and enhancing drainage of ascites in mice with liver fibrosis

Ji-cheng LI; Shu-hui Yuan; Jian-pei Zhao; Zhi-liang Lu

doi:10.1007/BF02935019

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Study on the effect of Chinese herbal medicine in regulating peritoneal lymphatic stomata and enhancing drainage of ascites in mice with liver fibrosis

Updated：2021-08-27

- Study on the effect of Chinese herbal medicine in regulating peritoneal lymphatic stomata and enhancing drainage of ascites in mice with liver fibrosis
- Chinese Journal of Integrative Medicine Vol. 7, Issue 2, Pages: 121-125(2001)
- Affiliations：
  
  Division of Lymphology, Department of Histology and Embryology, Medical School of Zhejiang University,Hangzhou
- Author bio：
- Funds：
  
  This article was funded by the National Foundation of Natural Sciences (No.39970934), fund for Scientific Researches by Science Committee of Hangzhou, fund for focal projects by State Administration of TCM (No. 972031), funded by Zhejiang Provincial Administration of TCM, special fund for excellent young talented person by Ministry of Health, and Analysis and Testing fund of Zhejiang Province
- DOI：10.1007/BF02935019
  CLC：
- Published：2001，
Scan for full text
LI, Jc., Yuan, Sh., Zhao, Jp. et al. Study on the effect of Chinese herbal medicine in regulating peritoneal lymphatic stomata and enhancing drainage of ascites in mice with liver fibrosis., CJIM 7, 121–125 (2001). https://doi.org/10.1007/BF02935019

Ji-cheng LI, Shu-hui Yuan, Jian-pei Zhao, et al. Study on the effect of Chinese herbal medicine in regulating peritoneal lymphatic stomata and enhancing drainage of ascites in mice with liver fibrosis. [J]. Chinese Journal of Integrative Medicine 7(2):121-125(2001)
LI, Jc., Yuan, Sh., Zhao, Jp. et al. Study on the effect of Chinese herbal medicine in regulating peritoneal lymphatic stomata and enhancing drainage of ascites in mice with liver fibrosis., CJIM 7, 121–125 (2001). https://doi.org/10.1007/BF02935019 DOI：

Ji-cheng LI, Shu-hui Yuan, Jian-pei Zhao, et al. Study on the effect of Chinese herbal medicine in regulating peritoneal lymphatic stomata and enhancing drainage of ascites in mice with liver fibrosis. [J]. Chinese Journal of Integrative Medicine 7(2):121-125(2001) DOI： 10.1007/BF02935019.

摘要

Objective: To observe the regulating effect of Chinese herbal medicine on peritoneal lymphatic stomata and its significance in treating ascites in liver fibrosis model mice.Methods: Two Chinese herbal compound prescriptions were used separately to treat the carbon tetrachloride induced mouse model of liver fibrosis

the histo-pathologic changes in mice were observed by using scanning electron microscope and processed by computer image processing. The changes of urinary volume and sodium ion concentration were measured

too.Results: In the treated group

the histo-pathologic changes were significantly less than those in the control group

the peritoneal lymphatic stomata enlarged with increased number of opening and higher density in distribution and the urinary volume and sodium ion excretion increased after treatment.Conclusion: Chinese herbal medicine has marked effect in alleviating liver fibrosis

regulating peritoneal lymphatic stomata

improving the drainage of ascites from peritoneal cavity

causing increase of urinary volume and sodium ion excretion to reduce water and sodium retention

and thus have favorable therapeutic effect in treating ascites.

Abstract

too.Results: In the treated group

the histo-pathologic changes were significantly less than those in the control group

regulating peritoneal lymphatic stomata

improving the drainage of ascites from peritoneal cavity

causing increase of urinary volume and sodium ion excretion to reduce water and sodium retention

and thus have favorable therapeutic effect in treating ascites.

关键词

Chinese Herbal MedicineLiver Fibrosisperitoneal lymphatic stomataasciteshisto-pathologyurinary volumeurinary ionic concentration

Keywords

Chinese Herbal MedicineLiver Fibrosisperitoneal lymphatic stomataasciteshisto-pathologyurinary volumeurinary ionic concentration

references

Ballardini G, Fallani M, Biagini G, et al. Desmin and actin in the identification Ito cells and in monitoring their evolution to myofibroblasts in experimental liver fibrosis. Virchows Achiv B Cell Pathol 1998; 56(1): 45–49.

Runyon Ba, Sugano S, Kanel G. A rodent model of cirrhosis, ascites, and bacterial peritonitis. Gastroenterology 1991;100(3):489–493.

Li J, LI YH, XUE JC, et al. Protective effect of Tanshinine on experimental damage of hepatocytes. Chinese J of Integrated Traditional and Western Medicine on Liver Dis 1996;6(3):29–31.

Wang Lt. The cytological mechanism of Chinese herbal medicines in antagonizing liver fibrosis. Chinese J of Integrated Traditional and Western Medicine on Liver Dis 1997:7(4):249–252.

Li J, Yu S. Study on the ultrastructure of the peritoneal stomata in humans. Acta Anat 1991; 141(1):26–31.

Li J, Lu Z, Wu N, et al. A scanning electron microscopy and computer image processing morphometric study of the pharmacological regulation of patency of the peritoneal stomata. Acta Anat 1996:178(5):443–447.

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Related Institution

The First Affiliated Hospital of Anhui College of Traditional Chinese Medicine

The First Affiliated Hospital, Zhejiang University School of Medicine

Institute of Liver Diseases, Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine

Institute of Traditional Chinese Internal Medicine, Shanghai Municipal Education Commission, Shanghai

Key Laboratory of Liver and Kidney Diseases, Shanghai University of Traditional Chinese Medicine

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