Objective: To assess the effect of Gusong II in treating postmenopausal osteoporosis and try to reveal its mechanism.Methods: Thirty-five women

49 to 62 years old

with 5.6 years menopause

were treated as the subjects and followed-up for 6 months

12 months or 24 months. The course of treatment ranged from 6 months to 25 months with an average of 14 months. Some related biochemical parameters

such as serum estradiol (E2)

testosterone (T)

the ratio of fasting urinary calcium to creatinine (Ca/Cr)

the ratio of 24h urinary calcium to creatinine (24h Ca/Cr)

24h urinary E2

and 24h urinary hydroxyproline (HOP) were measured before and after treatment.Results: After 6~9 months or 1~2 years of treatment

the levels of serum E2 and 24h urinary E2 were raised significantly

while the levels of serum T and urinary Ca/Cr fell evidently after one or two year’s treatment. The levels of serum E2 and 24h urinary E2 were significantly correlated with the levels of fasting urinary Ca/Cr

24h urinary Ca/Cr

serum T

and 24h urinary HOP respectively.Conclusions: Gusong-II can elevate the serum E2 levels of postmenopausal women

reduce the discharge of urinary calcium and HOP

and inhibit bone resorption. The rise of the serum E2 level might be correlated with the conversion of T to E2.