Objective: To assess the effects of Xianzhen tablet (XZT) on Na+-K+-ATPase and Ca2+-Mg2+-ATPase on erythrocytic membranes

viscosity of whole blood

plasma glucose and clinical manifestations.Methods: Seventy-two cases of non-insulin-dependent diabetes mellitus (NIDDM) patients with deficiency of both Qi and Yin

deficiency of the Kidney and blood stasis were selected

and the effects of treatment on Na+ K+ -ATPase

Ca2+-Mg2+-ATPase

whole blood viscosity

blood sugar and clinical symptoms were observed.Results: In XZT group (test group)

activities of Na+ -K+ -ATPase and Ca2+ -Mg2+ -ATPase rose significantly (P < 0.01

P < 0.05) after treatment. Viscosity of whole blood and clinical manifestations also improved obviously. The total effective rate in lowering plasma glucose was 77.8% with fasting blood glucose (FBG) and 69. 4% with 2 hours postprandial plasma blood glucose (2°PBG). In the control group

viscosity of whole blood and clinical manifestations had no significant improvement. Its total effective rate in lowering plasma glucose was 41.7% with FBG and 38.9% with 2°PBG.Conclusions: XZT played a certain role in increasing activities of Na+ -K+ -ATPase and Ca2+ -Mg2+ -ATPase

decreasing viscosity of whole blood and plasma glucose and improving clinical manifestations. Therefore

XZT was experimentally manifested as an effective drug in treating NIDDM patients with Qi-Yin deficiency

renal deficiency and blood stasis.