Effect of Reduqing ( ) on endotoxin-lnduced production of tissue factor and cytokines in human whole blood) on endotoxin-lnduced production of tissue factor and cytokines in human whole blood

Wun Tzechein; Li Anguo; Li Mingzhen; Lu Fuer

doi:10.1007/BF02935050

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Effect of Reduqing ( ) on endotoxin-lnduced production of tissue factor and cytokines in human whole blood) on endotoxin-lnduced production of tissue factor and cytokines in human whole blood

Updated：2021-08-27

- Effect of Reduqing ( ) on endotoxin-lnduced production of tissue factor and cytokines in human whole blood) on endotoxin-lnduced production of tissue factor and cytokines in human whole blood
- Chinese Journal of Integrative Medicine Vol. 4, Issue 1, Pages: 43-47(1998)
- Affiliations：
  
  1. Searle-Monsanto Co.,USA
  2. Institution of Integration of Traditional Chinese and Western Medicine, Tongji Medical University,Wuhan,P. R. China
- Author bio：
- Funds：
- DOI：10.1007/BF02935050
  CLC：
- Published：1998，
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Tzechein, W., Anguo, L., Mingzhen, L. et al. Effect of Reduqing () on endotoxin-lnduced production of tissue factor and cytokines in human whole blood) on endotoxin-lnduced production of tissue factor and cytokines in human whole blood., CJIM 4, 43–47 (1998). https://doi.org/10.1007/BF02935050

Wun Tzechein, Li Anguo, Li Mingzhen, et al. Effect of Reduqing ( ) on endotoxin-lnduced production of tissue factor and cytokines in human whole blood) on endotoxin-lnduced production of tissue factor and cytokines in human whole blood. [J]. Chinese Journal of Integrative Medicine 4(1):43-47(1998)
Tzechein, W., Anguo, L., Mingzhen, L. et al. Effect of Reduqing () on endotoxin-lnduced production of tissue factor and cytokines in human whole blood) on endotoxin-lnduced production of tissue factor and cytokines in human whole blood., CJIM 4, 43–47 (1998). https://doi.org/10.1007/BF02935050 DOI：

Wun Tzechein, Li Anguo, Li Mingzhen, et al. Effect of Reduqing ( ) on endotoxin-lnduced production of tissue factor and cytokines in human whole blood) on endotoxin-lnduced production of tissue factor and cytokines in human whole blood. [J]. Chinese Journal of Integrative Medicine 4(1):43-47(1998) DOI： 10.1007/BF02935050.

摘要

Objective: To study the effect of Reduqing (RDQ) Injection on the lipopolysaccharide (LPS)-induced tissue factor and cytokine production in whole blood. Methods: Heparinized human blood was incubated with LPS in the presence or absence of RDQ. The plasma concentrations of TNF-α

IL-1β

IL-6

and IL-8 were measured by enzyme-linked immunosorbent assays (ELISA) and the monocyte tissue factor activity was measured by a one-stage tissue factor induced plasma clotting time assay. Results: RDQ was found to diminish the LPS-induced increase of TNF-α

IL-1β and IL-6 in plasma but did not completely abolish their production. In contrast to the effect on these cytokines

RDQ caused further increase of the plasma level of IL-8 and the monocyte TF activity in the presence of LPS. Conclusions: In the in vitro whole blood assay system used in this study

the decrease of LPS-induced production of TNF-α

IL-1β

and IL-6 was similar to a previousin vivo study on the effect of RDQ on the production of these cytokines in response to two-time LPS injection in rabbits

while the increase of IL-8 and TF production was contradictory to the previous in vivo study. Potential reasons contributing to the differences are discussed.

Abstract

IL-1β

IL-6

IL-1β and IL-6 in plasma but did not completely abolish their production. In contrast to the effect on these cytokines

RDQ caused further increase of the plasma level of IL-8 and the monocyte TF activity in the presence of LPS. Conclusions: In the in vitro whole blood assay system used in this study

the decrease of LPS-induced production of TNF-α

IL-1β

and IL-6 was similar to a previousin vivo study on the effect of RDQ on the production of these cytokines in response to two-time LPS injection in rabbits

while the increase of IL-8 and TF production was contradictory to the previous in vivo study. Potential reasons contributing to the differences are discussed.

关键词

Reduqingtissue factortumor necrosis factor-αinterleukin-lβinterleukin-6interleukin-8lipopolysaccharidemonocytesmononuclear cells

Keywords

Reduqingtissue factortumor necrosis factor-αinterleukin-lβinterleukin-6interleukin-8lipopolysaccharidemonocytesmononuclear cells

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Department Respiratory of Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology

Department Emergency of Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology

Beijing Institute of Traditional Chinese Medicine

Beijing Traditional Chinese Medicine Hospital Affiliated to Capital Medical University

Department of Hepatology, Zhejiang Hospital of Traditional Chinese Medicine

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