Clinical and Experimental Study of effects of rhubarb on gastrointestinal blood flow perfusion in critical illness

De-chang Chen; Xing-yi Yang; Xing-lu Jiang; Hong-jiang Li; Bing-wen Jing

doi:10.1007/BF02935096

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Clinical and Experimental Study of effects of rhubarb on gastrointestinal blood flow perfusion in critical illness

Updated：2021-08-27

- Clinical and Experimental Study of effects of rhubarb on gastrointestinal blood flow perfusion in critical illness
- Chinese Journal of Integrative Medicine Vol. 7, Issue 1, Pages: 2-6(2001)
- Affiliations：
  
  1. Shanghai Changzheng Hospital,Shanghai
  2. Department of Emergency and Critical Care Medicine, Shanghai Changzheng Hospital,Shanghai
- Author bio：
- Funds：
  
  Supported by National Natural Scientific Foundation, No. 39570688
- DOI：10.1007/BF02935096
  CLC：
- Published：2001，
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Chen, Dc., Yang, Xy., Jiang, Xl. et al. Clinical and Experimental Study of effects of rhubarb on gastrointestinal blood flow perfusion in critical illness., CJIM 7, 2–6 (2001). https://doi.org/10.1007/BF02935096

De-chang Chen, Xing-yi Yang, Xing-lu Jiang, et al. Clinical and Experimental Study of effects of rhubarb on gastrointestinal blood flow perfusion in critical illness. [J]. Chinese Journal of Integrative Medicine 7(1):2-6(2001)
Chen, Dc., Yang, Xy., Jiang, Xl. et al. Clinical and Experimental Study of effects of rhubarb on gastrointestinal blood flow perfusion in critical illness., CJIM 7, 2–6 (2001). https://doi.org/10.1007/BF02935096 DOI：

De-chang Chen, Xing-yi Yang, Xing-lu Jiang, et al. Clinical and Experimental Study of effects of rhubarb on gastrointestinal blood flow perfusion in critical illness. [J]. Chinese Journal of Integrative Medicine 7(1):2-6(2001) DOI： 10.1007/BF02935096.

摘要

Objective: To investigate the effect of rhubarb on gastrointestinal blood perfusion in critical illness and hemorrhagic shocked rats.Methods: Clinical Study: Sixty-four septic patients

who suffered from stress ulcer

were treated with rhubarb at a dose of 25 mg/kg. Twenty-five non-septic patients were taken as control. The gastrointestinal perfusion was evaluated by intramural pH (pHi). Animal study: SD rats were anesthetized with intraperitoneal sodium pentobarbital at a dose of 20 mg/kg. Blood-letting were performed in the animals. Blood pressure reduced to 5.32 kPa and maintained for 120 mins. They were resuscitated at the end of shock by reinfusing all of the shed blood. The rats were randomly divided into four groups: Normal control

shock group

therapeutic group (shocked rats were treated with 50 mg/kg rhubarb at the end of shock) and rhubarb group (normal rats were treated with rhubarb). Laser Doppler was applied to estimate the gastrointestinal blood perfusion.Results: Clinical Study: The gastrointestinal pHi in septic patients was much lower than that in the control

whereas rhubarb could obviously elevate gastrointestinal pHi (P < 0.001). In addition

rhubarb also had good effect on gastric hemorrhage caused by stress ulcer. Animal Study: Although the shocked rats were resuscitated completely

their gastrointestinal blood perfusion was much lower than that in the control. Rhubarb could significantly improve the blood perfusion in gastrointestinal mucosa and mesentery (P < 0.01). Furthermore

rhubarb also increase the gastrointestinal perfusion in normal rats.Conclusion: Rhubarb could improve gastrointestinal blood perfusion in critical illness and shocked rats.

Abstract

Objective: To investigate the effect of rhubarb on gastrointestinal blood perfusion in critical illness and hemorrhagic shocked rats.Methods: Clinical Study: Sixty-four septic patients

who suffered from stress ulcer

shock group

whereas rhubarb could obviously elevate gastrointestinal pHi (P < 0.001). In addition

rhubarb also had good effect on gastric hemorrhage caused by stress ulcer. Animal Study: Although the shocked rats were resuscitated completely

rhubarb also increase the gastrointestinal perfusion in normal rats.Conclusion: Rhubarb could improve gastrointestinal blood perfusion in critical illness and shocked rats.

关键词

rhubarbsepsisshockstomachintestinevolume of blood flow

Keywords

rhubarbsepsisshockstomachintestinevolume of blood flow

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Library of Guangzhou University of Chinese Medicine

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Institute of Clinical Pharmacology, Central South University

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