Clinical study on reversing hepatic fibrosis with Handan Ganle ( ) capsule) capsule

Ming-liang Cheng; Yin-ying Lu; Jun Wu; Tian-yong Luo; Yi-sheng Ding

doi:10.1007/BF02935100

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Clinical study on reversing hepatic fibrosis with Handan Ganle ( ) capsule) capsule

Updated：2021-08-27

- Clinical study on reversing hepatic fibrosis with Handan Ganle ( ) capsule) capsule
- Chinese Journal of Integrative Medicine Vol. 7, Issue 1, Pages: 16-18(2001)
- Affiliations：
  
  Department of Infectious Diseases, Affiliated Hospital, Guiyang Medical College,Guiyang
- Author bio：
- Funds：
  
  Supported by the Key Project of the “9th Five Year Plan” of Science Commission of Guizhou Province
- DOI：10.1007/BF02935100
  CLC：
- Published：2001，
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Cheng, Ml., Lu, Yy., Wu, J. et al. Clinical study on reversing hepatic fibrosis with Handan Ganle () capsule) capsule., CJIM 7, 16–18 (2001). https://doi.org/10.1007/BF02935100

Ming-liang Cheng, Yin-ying Lu, Jun Wu, et al. Clinical study on reversing hepatic fibrosis with Handan Ganle ( ) capsule) capsule. [J]. Chinese Journal of Integrative Medicine 7(1):16-18(2001)
Cheng, Ml., Lu, Yy., Wu, J. et al. Clinical study on reversing hepatic fibrosis with Handan Ganle () capsule) capsule., CJIM 7, 16–18 (2001). https://doi.org/10.1007/BF02935100 DOI：

Ming-liang Cheng, Yin-ying Lu, Jun Wu, et al. Clinical study on reversing hepatic fibrosis with Handan Ganle ( ) capsule) capsule. [J]. Chinese Journal of Integrative Medicine 7(1):16-18(2001) DOI： 10.1007/BF02935100.

摘要

Objective: To observe the therapeutic effect on hepatic fibrosis of chronic hepatitis B by Chinese medicine—Handan Ganle capsule (HDGLC).Methods: A total of 104 patients with chronic hepatitis B has been treated by HDGLC for 6 months

liver fibrosis indexes and the serum biochemical indexes were detected before treatment

during the curative period and by the end of treatment. Hepatic biopsy was performed before or after the treatment.Results: The improvement rate of clinical symptoms was 79.0% - 90.6%

and the recovery rate of ALT was 72.6 %

serum fibrosis indexes such as HA

type IV collagen and LN were significantly decreased along with the extending course of disease (P < 0.05). The pathohistological score of liver was decreased from 7.82 ± 6.22 before treatment to 5.16 ± 3.75 after treatment (P < 0.05) and the score of hepatic fibrosis was decreased from 7.49 ± 5.45 before treatment to 5.16 ± 4.26 after treatment (P < 0.05).Conclusion: HDGLC has remarkable therapeutic and reversing effect on chronic hepatitis B induced hepatic fibrosis.

Abstract

liver fibrosis indexes and the serum biochemical indexes were detected before treatment

during the curative period and by the end of treatment. Hepatic biopsy was performed before or after the treatment.Results: The improvement rate of clinical symptoms was 79.0% - 90.6%

and the recovery rate of ALT was 72.6 %

serum fibrosis indexes such as HA

关键词

Liver Fibrosishepatitis BHandan Ganle capsule

Keywords

Liver Fibrosishepatitis BHandan Ganle capsule

references

Cheng ML, Liu SD. The basic study and clinical practice on hepatic fibrosis. 1st, edition. Beijing: People’ s Health Publishing House, 1996:228–258.

Conference on Infectious Disease and Parasitic Disease of Chinese Medical Association. Prevention and treatment program on viral hepatitis (provisional). Chin J Infec Dis 1995; 13:241–247.

Knodell KG, Ishak KG. Formulation and application of a numerical scoring system for assessing histological activity in asymptomatic chronic active hepatitis. Hepatology 1981; 1: 431–435.

Chwvallire M, Guerret S. A histological semi-quantitative scoring system for evaluation of hepatic fibrosis in needle liver biopsy specimens-comparison with morphormetive studies. Hepatology 1992; 22:349–355.

Li W, Dai QT, Liu ZE, et al. The primary observation on early hepatic fibrosis of chronic hepatitis B treated by Gingko biloba granule. CJITWM 1995; 15(10): 593–595.

Ma H, Wang BE, Chen YY, et al. The experimental study of treatment effect of the milkvetch on hepatic fibrosis. Chin J Hepatology 1997; 5(1): 32.

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Related Institution

Key Laboratory of Liver and Kidney Diseases, Shanghai University of Traditional Chinese Medicine

Institute of Traditional Chinese Internal Medicine, Shanghai Municipal Education Commission, Shanghai

Institute of Liver Diseases, Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine

Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Institute of Liver Diseases, Shanghai University of Chinese medicine

Department of Gastroenterology, Shanghai East Hospital Affiliated to Tongji University

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