Objective: To observe the efficacy of Astragalus-Polygonum Anti-Fibrosis decoction (APAFD) and Jinshuibao capsule (JSBC) in treating liver fibrosis of chronic hepatitis B.Methods: Ninety-two cases of liver fibrosis of chronic hepatitis B were randomly divided into group A and group B. Patients in group A received APAFD for 48 weeks

and in group B

they received JSBC for 48 weeks. The effects on the level change of hyaluronic acid (HA)

laminin (LN)

pro-collagen III (PCIII) and collagen IV (CIV) as well as liver functional tests and liver biochemical parameters before and after treatment were observed.Results: Level of serum HA

LN

PCIII and CIV in group A declined more obviously than that of group B

the difference was significant (P < 0.01). The liver functional tests such as total bilirubin (TB)

alanine aminotransferase (ALT)

albumin/ globulin (A/G) ratio

hepatitis related serum biochemical parameters such as cholylglycine (CG)

serum ferritin (SF)

prealbumin (PC) of group A were all improved more significantly than that of group B (P < 0.01).Conclusion: APAFD is more effective than JSBC in treating liver fibrosis of chronic hepatitis B and in the inhibition of hepatic inflammation

hence it is a good composite Chinese herbal preparation against liver fibrosis.