A comparative study on the therapeutic effect of Astragaloside ( ) and Perindopril in treating CVB3-infected cardiomyocytes in rats) and Perindopril in treating CVB3-infected cardiomyocytes in rats

Chen Xiang-jian; Lu Shu; Ji-nan Zhang; Wen-zhu Ma

doi:10.1007/BF02935108

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A comparative study on the therapeutic effect of Astragaloside ( ) and Perindopril in treating CVB3-infected cardiomyocytes in rats) and Perindopril in treating CVB3-infected cardiomyocytes in rats

Updated：2021-08-27

- A comparative study on the therapeutic effect of Astragaloside ( ) and Perindopril in treating CVB3-infected cardiomyocytes in rats) and Perindopril in treating CVB3-infected cardiomyocytes in rats
- Chinese Journal of Integrative Medicine Vol. 7, Issue 1, Pages: 39-42(2001)
- Affiliations：
  
  Research Institute of Cardiovascular Diseases, The First Affiliated Hospital of Nanjing Medical University,Nanjing
- Author bio：
- Funds：
  
  This study was supported by National Natural Science Foundation (96-906-02-13), Science Commission Social Development Foundation of Jian-gsu Province (BS97028 and BS98039) and Health Bureau of Jiangsu Province (H9701).
- DOI：10.1007/BF02935108
  CLC：
- Published：2001，
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Xiang-jian, C., Shu, L., Zhang, Jn. et al. A comparative study on the therapeutic effect of Astragaloside () and Perindopril in treating CVB3-infected cardiomyocytes in rats) and Perindopril in treating CVB3-infected cardiomyocytes in rats., CJIM 7, 39–42 (2001). https://doi.org/10.1007/BF02935108

Chen Xiang-jian, Lu Shu, Ji-nan Zhang, et al. A comparative study on the therapeutic effect of Astragaloside ( ) and Perindopril in treating CVB3-infected cardiomyocytes in rats) and Perindopril in treating CVB3-infected cardiomyocytes in rats. [J]. Chinese Journal of Integrative Medicine 7(1):39-42(2001)
Xiang-jian, C., Shu, L., Zhang, Jn. et al. A comparative study on the therapeutic effect of Astragaloside () and Perindopril in treating CVB3-infected cardiomyocytes in rats) and Perindopril in treating CVB3-infected cardiomyocytes in rats., CJIM 7, 39–42 (2001). https://doi.org/10.1007/BF02935108 DOI：

Chen Xiang-jian, Lu Shu, Ji-nan Zhang, et al. A comparative study on the therapeutic effect of Astragaloside ( ) and Perindopril in treating CVB3-infected cardiomyocytes in rats) and Perindopril in treating CVB3-infected cardiomyocytes in rats. [J]. Chinese Journal of Integrative Medicine 7(1):39-42(2001) DOI： 10.1007/BF02935108.

摘要

Objective: To compare the therapeutic effects of Astragaloside and Perindopril on myocardial sarco/endoplasmic reticulum Ca2+ -ATPase (SERCA) activity and the SERCA type 2 mRNA level in Coxsack-ievirus B3 (CVB3)-infected cardiomyocytes.Methods: Cultured cardiomyocytes of rats were divided into normal

model

Astragaloside and Perindopril groups. The model

Astragaloside and Perindopril groups were infected with CVB3. Meanwhile

the Astragaloside and the Perindopril groups were treated with Astragaloside (10 μg/ml) and Perindopril (1.3 μg/ml) respectively. Cytopathic effect (CPE)

cardiac troponin I (cTnI)

the SERCA activity and mRNA level of the SERCA type 2 were observed after 96 hours.Results: The CPE and cTnI of model group were significantly higher than those of normal

Astragaloside and Perindopril groups (P< 0.01). The activity and the mRNA expression of myocardial SERCA of model group were significantly lower than those of normal

Astragaloside and Perindopril groups (P < 0.01-0.05). Compared with Astragaloside group

the CPE

cTnI of Perindopril group were higher and the activity and mRNA level of Perindopril group were lower. But there were no significant difference between the two groups (P >0.05).Conclusion: Astragaloside and Perindopril were able to reverse the down-regulations of cardiac SERCA activity and mRNA expression caused by virus infection to alleviate the cardiomyocyte injury.

Abstract

model

Astragaloside and Perindopril groups. The model

Astragaloside and Perindopril groups were infected with CVB3. Meanwhile

the Astragaloside and the Perindopril groups were treated with Astragaloside (10 μg/ml) and Perindopril (1.3 μg/ml) respectively. Cytopathic effect (CPE)

cardiac troponin I (cTnI)

the SERCA activity and mRNA level of the SERCA type 2 were observed after 96 hours.Results: The CPE and cTnI of model group were significantly higher than those of normal

Astragaloside and Perindopril groups (P< 0.01). The activity and the mRNA expression of myocardial SERCA of model group were significantly lower than those of normal

Astragaloside and Perindopril groups (P < 0.01-0.05). Compared with Astragaloside group

the CPE

关键词

AstragalosidePerindoprilcardiomyocyte cultureCoxsackievirus B3sarco/endoplasmic reticulum Ca2+ -ATPase

Keywords

AstragalosidePerindoprilcardiomyocyte cultureCoxsackievirus B3sarco/endoplasmic reticulum Ca2+ -ATPase

references

Anandasabapathy S, Frishman W.H. Innovative drug treatments for viral and autoimmune myocarditis: J Clin Pharmacol 1998; 38: 295–308.

ZHANG JN, YANG GP, SU EB, et al. The study of serum cardiac troponin I in diagnosing acute myocardial infarction. J of Chin Cardiovas Disea 1997; 25(5): 379–382.

ZHU BH, ZHANG JN, LIU NF, et al. The experimental study of relationship between left ventricular hypertrophy in hypertension and cardiac sarcoplasmic calcium-regulated protein. J of Chin Med 1999; 79(4): 286–288.

ZHANG JN, SU EB, WEI J, et al. Elevation of cardiac troponin I and its association with diagnosis and progress of viral myocarditis. Clin J Cardiol 1999; 27(6): 1–4.

Arai M, Matsui H, Periasamy M. Sarcoplasmic Reticulum Gene Expression in Cardiac Hypertrophy and Heart Failure. Circ Res 1994; 74: 555–564.

LU S, ZHANG JN. The study on progress of cardiovascular pharmacological effects of Astragalus. Chin Herbs 1998; 29 (1): 59–61.

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State Discipline and State Key Laboratory of Kidney Disease (Chinese PLA General Hospital, 2011DAV)

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