A study on protective action of Astragalus Injection( )in ouabain-induced cardiac Toxicity of guinea pigs)in ouabain-induced cardiac Toxicity of guinea pigs

Zhong-qi Yang; Shao-xiang Xian; Ming-ping Liu; Qian-wei Chen; Hui-ping Zheng; Li-cheng Zhao

doi:10.1007/BF02935112

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A study on protective action of Astragalus Injection( )in ouabain-induced cardiac Toxicity of guinea pigs)in ouabain-induced cardiac Toxicity of guinea pigs

Updated：2021-08-27

- A study on protective action of Astragalus Injection( )in ouabain-induced cardiac Toxicity of guinea pigs)in ouabain-induced cardiac Toxicity of guinea pigs
- Chinese Journal of Integrative Medicine Vol. 7, Issue 1, Pages: 48-49(2001)
- Affiliations：
  
  Cardiovascular Department, The First Affiliated Hospital of Guangzhou University of Traditional Chinese Medicine and Pharmacology,Guangzhou
- Author bio：
- Funds：
  
  This subject is supported by the Scientific Research Fund of Guangzhou University of Traditional Chinese Medicine and Pharmacology (No. 9764)
- DOI：10.1007/BF02935112
  CLC：
- Published：2001，
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Yang, Zq., Xian, Sx., Liu, Mp. et al. A study on protective action of Astragalus Injection()in ouabain-induced cardiac Toxicity of guinea pigs)in ouabain-induced cardiac Toxicity of guinea pigs., CJIM 7, 48–49 (2001). https://doi.org/10.1007/BF02935112

Zhong-qi Yang, Shao-xiang Xian, Ming-ping Liu, et al. A study on protective action of Astragalus Injection( )in ouabain-induced cardiac Toxicity of guinea pigs)in ouabain-induced cardiac Toxicity of guinea pigs. [J]. Chinese Journal of Integrative Medicine 7(1):48-49(2001)
Yang, Zq., Xian, Sx., Liu, Mp. et al. A study on protective action of Astragalus Injection()in ouabain-induced cardiac Toxicity of guinea pigs)in ouabain-induced cardiac Toxicity of guinea pigs., CJIM 7, 48–49 (2001). https://doi.org/10.1007/BF02935112 DOI：

Zhong-qi Yang, Shao-xiang Xian, Ming-ping Liu, et al. A study on protective action of Astragalus Injection( )in ouabain-induced cardiac Toxicity of guinea pigs)in ouabain-induced cardiac Toxicity of guinea pigs. [J]. Chinese Journal of Integrative Medicine 7(1):48-49(2001) DOI： 10.1007/BF02935112.

摘要

Objective: To study the protective action of Astragalus Injection (AI) on ouabain-induced cardiac toxicity.Methods: Forty guinea-pigs were randomly divided into the AI group and the control group

AI injected intravenously in the AI group and 0.9% normal saline injected in the control group

ouabain was injected in contralateral of both groups intravenously 8 mins later. The time of cardiac ventricular tachycardia (VT) and cardiac ventricular fibrillation (VF)

and the dose of ouabain were documented.Results: Compared with the control group AI could markedly prolong the time of VT and VF

and increase the dose of ouabain induces VT and VF (P < 0.01).Conclusion: AI decreases the incidence of digitalism.

Abstract

Objective: To study the protective action of Astragalus Injection (AI) on ouabain-induced cardiac toxicity.Methods: Forty guinea-pigs were randomly divided into the AI group and the control group

AI injected intravenously in the AI group and 0.9% normal saline injected in the control group

ouabain was injected in contralateral of both groups intravenously 8 mins later. The time of cardiac ventricular tachycardia (VT) and cardiac ventricular fibrillation (VF)

and the dose of ouabain were documented.Results: Compared with the control group AI could markedly prolong the time of VT and VF

and increase the dose of ouabain induces VT and VF (P < 0.01).Conclusion: AI decreases the incidence of digitalism.

关键词

Radix Astragalisouabaincardiac toxicity

Keywords

Radix Astragalisouabaincardiac toxicity

references

Yang ZQ, Liu MP. Effects of Astragalus injection on incidence of digitalism during the treatment of congestive heart failure. Tradi Chin Drug Res and Clin Phar 1998; 9(2): 80–81.

He BX. The cardiac glycoside clinical application. Chin J Cardi 1991; 19(1): 50–51.

Wang BX. Contemporary Chinese medicinal herb pharmacology. Tianjin: Science and Technology Publishing House, 1997: 1175–1176.

Xu SY. Pharmacological experimental methodology. 2nd. Beijing: People’ s Health Publishing House, 1994: 1015–1020.

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