Effect of ligustrazine on kanamycin ototoxicity

Wan-dong She; Zhao-he Chen

doi:10.1007/BF02935132

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Effect of ligustrazine on kanamycin ototoxicity

Updated：2021-08-27

- Effect of ligustrazine on kanamycin ototoxicity
- Chinese Journal of Integrative Medicine Vol. 3, Issue 3, Pages: 179-182(1997)
- Affiliations：
  
  Department of Otolaryngology, Affiliated Drum Tower Hospital, Medical College of Nanjing University,Nanjing
- Author bio：
- Funds：
  
  Supported by fund form Burean of Jiangsu Province
- DOI：10.1007/BF02935132
  CLC：
- Published：1997，
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She, Wd., Chen, Zh. Effect of ligustrazine on kanamycin ototoxicity., CJIM 3, 179–182 (1997). https://doi.org/10.1007/BF02935132

Wan-dong She, Zhao-he Chen. Effect of ligustrazine on kanamycin ototoxicity. [J]. Chinese Journal of Integrative Medicine 3(3):179-182(1997)
She, Wd., Chen, Zh. Effect of ligustrazine on kanamycin ototoxicity., CJIM 3, 179–182 (1997). https://doi.org/10.1007/BF02935132 DOI：

Wan-dong She, Zhao-he Chen. Effect of ligustrazine on kanamycin ototoxicity. [J]. Chinese Journal of Integrative Medicine 3(3):179-182(1997) DOI： 10.1007/BF02935132.

摘要

Objective: To evaluate the effect of ligustrazine on kanamycin ototoxicity.Methods: By measuring superoxide dismutase (SOD) and malondialdehyde (MDA) in cochlear tissues

compound action potentials (CAP) and cochlear microphonics (CM) in guinea-pigs which were treated with kanamycin and ligustrazine. Results: Kanamycin produced a severe hearing loss and significant increase in SOD and MDA. Ligustrazine could reduce these changes significantly and improve hearing of animals. Conclusion: Lipid peroxidative reaction is correlated with kanamycin ototoxicity and ligustrazine could prevent and treat kanamycin ototoxicity by antioxidation.

Abstract

Objective: To evaluate the effect of ligustrazine on kanamycin ototoxicity.Methods: By measuring superoxide dismutase (SOD) and malondialdehyde (MDA) in cochlear tissues

关键词

Ligustrazinekanamycin ototoxicitycochleasuperoxide dismutasemalondialdehyde

Keywords

Ligustrazinekanamycin ototoxicitycochleasuperoxide dismutasemalondialdehyde

references

1991; (10): 27.

Ohkawa H, Ohishi N, Yagi K. Assay for lipid peroxide in animal tissues by thiobanbituric acid reaction. Annal Biochem 1979; 95: 351.

1993: 28: 79.

McCord JM. Oxygen-derived free radicals in postischemic tissue injury. New Engl J Med 1985; 312: 159.

1991: 26: 18.

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