Objective: Try to find out the objective parameters of Syndrome Differentiation of diabetic nephropathy.Methods: By radio-immunoassay technique

some parameters

including glucoprotein

microglobulins

immunoglobulins

etc. of 41 diabetic nephropathy patients of the Deficiency of Spleen-Kidney and Qiblood type and Yang Deficiency causing edema with upward gush of Turbid Yin type were measured and analysed.Results: β2-microglobulin

α1-microglobulin in blood rose significantly in both types. There was significant difference between the two types in microglobulins

also in atrial natriuretic polypeptins

pancreatic glucagon in blood

and β2-microglobulin

immunoglobulin G

albumin

secretory immunoglobulin A in urine.Conclusion: Above-mentioned parameters offered some objective data on Syndrome Differentiation of diabetic nephropathy and this is vital in guiding the Syndrome Differentiation and treatment of this disease.