Experimental study on effect of Cordyceps sinensis on renal protection, urinary enzymes and nephrotoxicity of cyclosporine a in rats

Xue-Zhi Zhao; Lei-shi Li

doi:10.1007/BF02935147

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Experimental study on effect of Cordyceps sinensis on renal protection, urinary enzymes and nephrotoxicity of cyclosporine a in rats

Updated：2021-08-27

- Experimental study on effect of Cordyceps sinensis on renal protection, urinary enzymes and nephrotoxicity of cyclosporine a in rats
- Chinese Journal of Integrative Medicine Vol. 3, Issue 3, Pages: 213-216(1997)
- Affiliations：
  
  1. Department of Nephrology, Changzheng Hospital,Shanghai
  2. The General Hospital of Nanjing Military District,Nanjing
- Author bio：
- Funds：
- DOI：10.1007/BF02935147
  CLC：
- Published：1997，
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Zhao, XZ., Li, Ls. Experimental study on effect of Cordyceps sinensis on renal protection, urinary enzymes and nephrotoxicity of cyclosporine a in rats., CJIM 3, 213–216 (1997). https://doi.org/10.1007/BF02935147

Xue-Zhi Zhao, Lei-shi Li. Experimental study on effect of Cordyceps sinensis on renal protection, urinary enzymes and nephrotoxicity of cyclosporine a in rats. [J]. Chinese Journal of Integrative Medicine 3(3):213-216(1997)
Zhao, XZ., Li, Ls. Experimental study on effect of Cordyceps sinensis on renal protection, urinary enzymes and nephrotoxicity of cyclosporine a in rats., CJIM 3, 213–216 (1997). https://doi.org/10.1007/BF02935147 DOI：

Xue-Zhi Zhao, Lei-shi Li. Experimental study on effect of Cordyceps sinensis on renal protection, urinary enzymes and nephrotoxicity of cyclosporine a in rats. [J]. Chinese Journal of Integrative Medicine 3(3):213-216(1997) DOI： 10.1007/BF02935147.

摘要

Objective: To explore the protective effect ofCordyceps sinensis (CS) on nephrotoxicity of cyclosporine A (CsA) and its mechanism.Methods: The renal function of isolated perfused rats was observed before and after three months treatment by CS.Results: CS could improve the renal function

increase the volume of urine

Na+ and K+ excretion and inulin clearance rate

and reduce the resistance of renal perfusion. It was found that the activities of urinary N-acetyl-β-glucosaminidase (NAG)

γ-glutamyl transferase (γ-GT) and lactate dehydrogenase (LDH) were lower in the CS treatment group than those in the control group.Conclusion: CS could protect the kidney from damage against nephrotoxicity of CsA and improve the abnormality of renal hemodynamics.

Abstract

increase the volume of urine

Na+ and K+ excretion and inulin clearance rate

and reduce the resistance of renal perfusion. It was found that the activities of urinary N-acetyl-β-glucosaminidase (NAG)

关键词

yclosporine ACordyceps sinensisurinary enzymesisolated perfused rat

Keywords

yclosporine ACordyceps sinensisurinary enzymesisolated perfused rat

references

Sumpio B, Baue AE, Chaudry IH. Treatment with verapamil and adenosine triphosphate - MgCl2 reduces cyclosporine nephrotoxicity. Surgery 1987; 101:315.

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5/6 1991;4(4):397.

Myers BD. Cyclosporine nephrotoxicity. Kid Int 1986; 30:964.

Matthew E, Weir DK, Klassen SY, et al. Acute effects of intravenous cyclosporine on blood pressure, renal hemodynamics and urine prostaglandin production of healthy humans. Transplantation 1990; 19(1):41.

Myers BD, Sibley R, Newton, et al. The long - term course of cyclosporine associated chronic nephropathy. Kid Int 1988;33:590.

Tullio Beetani, Norberto Perico, Mauro Abbate, et al. Renal injury induced by long - term administration of CsA to rats. America Journal of Pathology 1987; 127(3):569.

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