Effect of Liuwei Dihuang decoction ( ) on long-term potentiation in hippocampal dentate gyms in rats) on long-term potentiation in hippocampal dentate gyms in rats

Zhou Jianzheng; Zhang Yongxiang; Liu Chuanhui; Zhou Jinhuang

doi:10.1007/BF02935177

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Effect of Liuwei Dihuang decoction ( ) on long-term potentiation in hippocampal dentate gyms in rats) on long-term potentiation in hippocampal dentate gyms in rats

Updated：2021-08-27

- Effect of Liuwei Dihuang decoction ( ) on long-term potentiation in hippocampal dentate gyms in rats) on long-term potentiation in hippocampal dentate gyms in rats
- Chinese Journal of Integrative Medicine Vol. 5, Issue 3, Pages: 209-213(1999)
- Affiliations：
  
  Beijing Institute of Pharmacology and Toxicology,Beijing
- Author bio：
- Funds：
  
  The study was supported by National Natural Science Foundation (No. 39570851) and The Climbing Program — The National Key Projects for Fundamental Research
- DOI：10.1007/BF02935177
  CLC：
- Published：1999，
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Jianzheng, Z., Yongxiang, Z., Chuanhui, L. et al. Effect of Liuwei Dihuang decoction () on long-term potentiation in hippocampal dentate gyms in rats) on long-term potentiation in hippocampal dentate gyms in rats., CJIM 5, 209–213 (1999). https://doi.org/10.1007/BF02935177

Zhou Jianzheng, Zhang Yongxiang, Liu Chuanhui, et al. Effect of Liuwei Dihuang decoction ( ) on long-term potentiation in hippocampal dentate gyms in rats) on long-term potentiation in hippocampal dentate gyms in rats. [J]. Chinese Journal of Integrative Medicine 5(3):209-213(1999)
Jianzheng, Z., Yongxiang, Z., Chuanhui, L. et al. Effect of Liuwei Dihuang decoction () on long-term potentiation in hippocampal dentate gyms in rats) on long-term potentiation in hippocampal dentate gyms in rats., CJIM 5, 209–213 (1999). https://doi.org/10.1007/BF02935177 DOI：

Zhou Jianzheng, Zhang Yongxiang, Liu Chuanhui, et al. Effect of Liuwei Dihuang decoction ( ) on long-term potentiation in hippocampal dentate gyms in rats) on long-term potentiation in hippocampal dentate gyms in rats. [J]. Chinese Journal of Integrative Medicine 5(3):209-213(1999) DOI： 10.1007/BF02935177.

摘要

Objective: To investigate effect of Liuwei Dihuang decoction (LWDHD)

a traditional Chinese medicinal prescription

on the formation of long-term potentiation (LTP) in the hippocampal dentate gyrus in anesthetized rats.Methods: LTP experiments were conducted by using a bipolar stimulating electrode to stimulate perforant pathway and a monopolar electrode to record the evoked field potential in hippocampal dentate gyrus. In the present study

both suprathreshold and subthreshold tetanic stimulation to the perforant pathway were employed.Results: Single oral administration of LWDHD (per os

5 g/kg and 10 g/kg respectively) has no effect on the basal spike amplitude. However

LWDHD (per os

5 g/kg and 10 g/kg respectively) significantly intensified the spike amplitude induced by a subthreshold stimulation (60 Hz

20 pulses) while it did not affect formation of LTP formation induced by suprathreshold tetanic stimulation (60 Hz

30 pulses).Conclusion: The present results suggested that LWDHD given orally potentiate the synaptic plasticity and transmission in hippocampal dentate gyrus

which might account for the enhancing effect of LWDHD on learning and memory in senescence-accelerated mice.

Abstract

Objective: To investigate effect of Liuwei Dihuang decoction (LWDHD)

a traditional Chinese medicinal prescription

both suprathreshold and subthreshold tetanic stimulation to the perforant pathway were employed.Results: Single oral administration of LWDHD (per os

5 g/kg and 10 g/kg respectively) has no effect on the basal spike amplitude. However

LWDHD (per os

5 g/kg and 10 g/kg respectively) significantly intensified the spike amplitude induced by a subthreshold stimulation (60 Hz

20 pulses) while it did not affect formation of LTP formation induced by suprathreshold tetanic stimulation (60 Hz

30 pulses).Conclusion: The present results suggested that LWDHD given orally potentiate the synaptic plasticity and transmission in hippocampal dentate gyrus

which might account for the enhancing effect of LWDHD on learning and memory in senescence-accelerated mice.

关键词

Liuwei Dihuang decoctiondentate gyruslong-term potentiationsynaptic plasticityrat

Keywords

Liuwei Dihuang decoctiondentate gyruslong-term potentiationsynaptic plasticityrat

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