Comparison between different effects gained by courses of different length in treating falciparum malaria with artesunate tablet

Guang-Qian Li; Yong-Xin Fu; Wei-Xiu Bian; Xing-Bo Guo

doi:10.1007/BF02935351

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Comparison between different effects gained by courses of different length in treating falciparum malaria with artesunate tablet

Updated：2021-08-27

- Comparison between different effects gained by courses of different length in treating falciparum malaria with artesunate tablet
- Chinese Journal of Integrative Medicine Vol. 3, Issue 2, Pages: 89-91(1997)
- Affiliations：
  
  Institute of Tropical Medicine, Guangzhou University of Traditional Chinese Medicine,Guangzhou
- Author bio：
- Funds：
- DOI：10.1007/BF02935351
  CLC：
- Published：1997，
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Li, GQ., Fu, YX., Bian, WX. et al. Comparison between different effects gained by courses of different length in treating falciparum malaria with artesunate tablet., CJIM 3, 89–91 (1997). https://doi.org/10.1007/BF02935351

Guang-Qian Li, Yong-Xin Fu, Wei-Xiu Bian, et al. Comparison between different effects gained by courses of different length in treating falciparum malaria with artesunate tablet. [J]. Chinese Journal of Integrative Medicine 3(2):89-91(1997)
Li, GQ., Fu, YX., Bian, WX. et al. Comparison between different effects gained by courses of different length in treating falciparum malaria with artesunate tablet., CJIM 3, 89–91 (1997). https://doi.org/10.1007/BF02935351 DOI：

Guang-Qian Li, Yong-Xin Fu, Wei-Xiu Bian, et al. Comparison between different effects gained by courses of different length in treating falciparum malaria with artesunate tablet. [J]. Chinese Journal of Integrative Medicine 3(2):89-91(1997) DOI： 10.1007/BF02935351.

摘要

Objective: To assess the efficacy of artesunate on falciparum malaria.Methods: A randomized and controlled study on the treatment of 90 uncomplicated falciparum malaria patients was carried out respectively with 400 mg of artesunate tablet as the total dose in 3 days

600 mg in 5 days and 800 mg in 7 days.Results: All patients were cured. Fever clearance time (FCT) and parasite clearance time (PCT) among the three groups were similar. Parasite recrudescence rates within 28 days were 39.3% (11/28) in the 3-day group

6.9% (2/ 29) in the 5-day group and 3.4% (1/29) in the 7-day group (comparing the 5-day group with the 3-day group

P < 0.005

comparing 7-day group with the 3-day group

P < 0.005).Conclusion: Parasite recrudescence rate may be effectively decreased by prolonging the treatment course.

Abstract

6.9% (2/ 29) in the 5-day group and 3.4% (1/29) in the 7-day group (comparing the 5-day group with the 3-day group

P < 0.005

comparing 7-day group with the 3-day group

P < 0.005).Conclusion: Parasite recrudescence rate may be effectively decreased by prolonging the treatment course.

关键词

artesunate tabletfalciparum malariaparasite recrudescence rate

Keywords

artesunate tabletfalciparum malariaparasite recrudescence rate

references

WHO Technical Report Series. Chemotherapy of malaria and resistance to antimalarials: Reorpt of a WHO Scientific Group. 1973; 529: 30–36.

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