Effects of Chinese Kidney-Tonifying herbal medicine on M-cholinergic receptor and acetylcholinesterase activity in dementia mimetic mice

Qi-Zhong Mo; Jun Ma; Bin Gong; Lian Ning; Bao-Mei Wang

doi:10.1007/BF02935371

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Effects of Chinese Kidney-Tonifying herbal medicine on M-cholinergic receptor and acetylcholinesterase activity in dementia mimetic mice

Updated：2021-08-27

- Effects of Chinese Kidney-Tonifying herbal medicine on M-cholinergic receptor and acetylcholinesterase activity in dementia mimetic mice
- Chinese Journal of Integrative Medicine Vol. 3, Issue 2, Pages: 127-130(1997)
- Affiliations：
  
  Nuclear Medicine Laboratory of Shanghai University of Traditional Chinese Medicine,Shanghai
- Author bio：
- Funds：
- DOI：10.1007/BF02935371
  CLC：
- Published：1997，
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Mo, QZ., Ma, J., Gong, B. et al. Effects of Chinese Kidney-Tonifying herbal medicine on M-cholinergic receptor and acetylcholinesterase activity in dementia mimetic mice., CJIM 3, 127–130 (1997). https://doi.org/10.1007/BF02935371

Qi-Zhong Mo, Jun Ma, Bin Gong, et al. Effects of Chinese Kidney-Tonifying herbal medicine on M-cholinergic receptor and acetylcholinesterase activity in dementia mimetic mice. [J]. Chinese Journal of Integrative Medicine 3(2):127-130(1997)
Mo, QZ., Ma, J., Gong, B. et al. Effects of Chinese Kidney-Tonifying herbal medicine on M-cholinergic receptor and acetylcholinesterase activity in dementia mimetic mice., CJIM 3, 127–130 (1997). https://doi.org/10.1007/BF02935371 DOI：

Qi-Zhong Mo, Jun Ma, Bin Gong, et al. Effects of Chinese Kidney-Tonifying herbal medicine on M-cholinergic receptor and acetylcholinesterase activity in dementia mimetic mice. [J]. Chinese Journal of Integrative Medicine 3(2):127-130(1997) DOI： 10.1007/BF02935371.

摘要

Objective: In order to study the effects of Chinese Kidney-tonifying (KT) herbal medicine on the M-cholinergic receptor(M-R) and the acetylcholinesterase(AchE) activity in the models’ cerebral cortex.Methods: Dementia mimetic mice models were formed with aluminum chloride.Results: The Muscarine receptor total receptor concentration (M-Rt) lowered and the AchE increased in the model significantly compared with healthy young mice. KT could markedly reduce the increase of AchE and elevate the lowered M-Rt in cerebral cortex of the dementia mimetic mice and improve the memory.Conclusions: KT is effective in preventing the degeneration of cerebral function and presenile dementia.

Abstract

关键词

Kidney-tonifyingdementia mimeticacetylcholinesteraseM-cholinergic receptor

Keywords

Kidney-tonifyingdementia mimeticacetylcholinesteraseM-cholinergic receptor

references

Heny I. Yanmamura. Neurotransmitter receptor binding. New York: Raven Press 1978:57–91.

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